◀ Back to IRF6

ADAM17 — IRF6

Text-mined interactions from Literome

Li et al., J Huazhong Univ Sci Technolog Med Sci 2002 : Study of the effects of LPS on the TACE gene expression and its function ... In order to investigate the effects of LPS on the TACE gene transcription and expression and its regulating effect on the TM-TNF secretion, in vitro studies were carried out on HL-60 cells stimulated by LPS ... ( 3 ) LPS also induced time-dependently increased expression of TACE gene and activation of its function
Hung et al., Placenta 2006 (Chorioamnionitis) : Our aim was to determine whether the expression of TACE is increased in human gestational tissues from pregnancies complicated by chorioamnionitis, and whether lipopolysaccharide (LPS) causes increased expression of TACE in the human gestational tissues in vitro
Brennan et al., Eur J Immunol 2008 : Using an ex vivo fluorogenic assay we observed that LPS rapidly induced TACE activity in monocytes coinciding with release of soluble TNF-alpha ... Paradoxically, both LPS with or without IL-10 led to accumulation of surface TACE ( albeit catalytically inactive ) over a 24 h period
Thorp et al., J Biol Chem 2011 : In a mouse model of endotoxemia, we discovered that LPS induced plasma sMER, and this was suppressed by Adam17 deficiency
Scott et al., J Biol Chem 2011 (MAP Kinase Signaling System) : LPS up-regulated TACE activity rapidly ( within 30 min ) without changing cell surface TACE expression ... Scavenging of ROS or inhibiting their production by flavoprotein oxidoreductases significantly attenuated LPS induced TACE activity up-regulation ... H ( 2 ) O ( 2 ) - and LPS induced TACE activity up-regulation were effectively abolished by a variety of selective p38 MAPK inhibitors ... In conclusion, our data indicate that in primary human monocytes, ROS mediate LPS induced up-regulation of TACE activity indirectly through activation of the p38 signaling pathway