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TNF — UCP2

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Lee et al., Hepatology 1999 (Necrosis) : Tumor necrosis factor increases mitochondrial oxidant production and induces expression of uncoupling protein-2 in the regenerating mice [ correction of rat ] liver
Masaki et al., Eur J Clin Invest 1999 (Anorexia) : To investigate functional modulators of uncoupling protein-2 (UCP2) gene expression, we examined the effects of TNF-alpha on UCP2 mRNA expression in rats ... TNF-alpha treatment induced an increase in UCP2 mRNA expression in broadly distributed tissues including brown adipose tissue (BAT), white adipose tissue ( WAT ) and skeletal muscle, and an elevation of ob gene mRNA expression in WAT
Tsuboyama-Kasaoka et al., Diabetes 2000 (Body Weight...) : Tumor necrosis factor (TNF)-alpha and uncoupling protein (UCP)-2 mRNA levels increased 12- and 6-fold, respectively, in isolated adipocytes from CLA fed mice compared with control mice
Merial et al., Am J Physiol Cell Physiol 2000 : The characterization of the mechanisms responsible for the TNF-alpha effect on UCP-2 expression demonstrates an involvement of the TNF-alpha induced inducible ( i ) nitric oxide synthase (NOS) expression ... Cell treatment with the NOS inhibitor N ( G ) -nitro-L-arginine methyl ester ( L-NAME ; 1 mmol/l ) significantly diminished the TNF-alpha mediated sustained downregulation of UCP-2 expression, whereas cell treatment with a nitric oxide ( NO ) donor ( 10 ( -3 ) mol/l S-nitroso-L-glutathione ) mimicked the TNF-alpha effect on UCP-2 expression
Nakatani et al., J Biol Chem 2002 : Peroxisome proliferator activated receptor-alpha ( PPARalpha ) activators, fish oil feeding, or fibrate administration up-regulated mitochondrial uncoupling protein ( UCP2 ) mRNA expression in mouse liver by 5-9-fold, whereas tumor necrosis factor-alpha (TNFalpha) also up-regulated UCP2 in liver
Uchino et al., J Surg Res 2004 (Fatty Liver...) : TNF-alpha further enhanced UCP-2 transcripts, inducing massive hepatocellular necrosis during acute rejection
Degasperi et al., FEBS Lett 2008 : Intracerebroventricular injection of tumor necrosis factor alpha (TNF-alpha) induced an increase of UCP2 expression in the hypothalamus, which was accompanied by increased expression of markers of oxidative stress and pro-apoptotic proteins
Faggioni et al., Biochem Biophys Res Commun 1998 (Escherichia coli Infections) : In liver, both IL-1 beta ( 1 microgram, i.p. ) and TNF ( 5 micrograms, i.p. ) increased UCP2 mRNA levels, 4- and 3-fold respectively, whereas in muscle and fat tissue, an increase was detectable after TNF, but not IL-1 beta
Cortez-Pinto et al., Biochem Biophys Res Commun 1998 : Futhermore, TNFalpha treatment induces UCP-2 mRNA accumulation in primary cultures of hepatocytes from healthy rats