Gene interactions and pathways from curated databases and text-mining

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LPA — TNF

Text-mined interactions from Literome

Panther et al., J Immunol 2002 (Calcium Signaling) : However, LPA inhibited in a pertussis toxin-insensitive manner the secretion of IL-12 and TNFalpha as well as enhanced secretion of IL-10 from mature DCs
Fan et al., Mol Med 2008 (Endotoxemia...) : LPA ( 1 and 10 microM ) significantly inhibited LPS induced TNFalpha production ( 61 +/- 9 % and 72 +/- 9 %, respectively, P < 0.05 ) but not IL-6
N'Diaye et al., Life Sci 2009 (Atherosclerosis) : Using the AhR antagonist alpha-napthtoflavone, the translational inhibitor cycloheximide and anti-tumor necrosis factor alpha (TNFalpha) neutralizing antibodies, we demonstrated that Lp(a) mediated mRNA induction of CCL1 occurs in an AhR independent manner and requires de novo protein synthesis of TNFalpha ... DNA binding activity of NF-kappaB, a well-known molecular effector of TNFalpha, was moreover activated by Lp(a) in a TNFalpha dependent manner and the use of the NF-kappaB inhibitor Bay 11-7082 blocked Lp(a) triggered CCL1 induction
Zhao et al., J Lipid Res 2011 (Inflammation) : TNF-alpha promotes LPA1- and LPA3 mediated recruitment of leukocytes in vivo through CXCR2 ligand chemokines
Nikitopoulou et al., J Exp Med 2012 (Arthritis, Experimental...) : ATX expression from SFs was induced by TNF , and LPA induced SF activation and effector functions in synergy with TNF
Skill et al., J Surg Res 2013 (Carcinoma, Hepatocellular...) : The 20 : 4 LPA selectively stimulated LPA receptor and tumor necrosis factor a expression in Hep3B cells, whereas 18 : 2 LPA did not
Netea et al., Infect Immun 1998 : Lipoprotein(a) inhibits lipopolysaccharide induced tumor necrosis factor alpha production by human mononuclear cells