Gene interactions and pathways from curated databases and text-mining

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CXCL12 — IL1A

Text-mined interactions from Literome

Han et al., J Clin Invest 2001 : TNF-alpha treatment mimicked SDF-1 alpha induction of NF-kappa B, IL-1 alpha/beta , and RANTES, as well as cell death ; neutralizing antibodies against TNF-alpha opposed these responses
Daly et al., Oral Oncol 2008 (Carcinoma, Squamous Cell...) : IL-1alpha and OSCC cell conditioned medium both stimulated HGF and SDF-1 expression, while TGF-beta(1) inhibited production of each factor
Sanmiguel et al., Cell Signal 2009 (Psoriasis) : Expression of CXCL9, CXCL10 and CXCL11 mRNAs was also increased in response to IL-1 , but protein could only be detected in medium from cells treated with IFN-gamma alone or in combination with IL-1
Ohashi et al., Hepatology research : the official journal of the Japan Society of Hepatology 2009 : Results : ( i ) IL-1alpha up-regulated mRNA levels of CXCL8 , CXCL10, and CCL2
Kogan-Sakin et al., Carcinogenesis 2009 : Prostate stromal cells produce CXCL-1, CXCL-2 , CXCL-3 and IL-8 in response to epithelia secreted IL-1
Voronov et al., J Immunotoxicol 2010 (Fibrosarcoma...) : SDF-1 and IL-6, each induced by IL-1 , were the two major cytokines whose levels differed in cell lines with or without IL-1
Olaru et al., J Invest Dermatol 2010 (Staphylococcal Skin Infections) : IL-1alpha and IL-1beta increased mRNA production and protein secretion of the neutrophil chemotactic CXCL1, CXCL2 , and IL-8 in keratinocytes
Stich et al., Res Vet Sci 2011 : Lipopolysaccharide was a more potent inducer of IL-1ß and CXCL-8 than LTA or PG and LTA is a more potent inducer of CXCL-8 than PG. Based on these data, PAMPs from gram positive and negative bacteria induce TNF, IL-1ß and CXCL-8 production in feline whole blood
Blaine et al., J Orthop Res 2011 (Bursitis...) : In cultured bursal synoviocytes, SDF-1a gene expression and protein production are stimulated by IL-1ß
Kitahara et al., Inflamm Res 2012 (Arthritis, Rheumatoid) : The mRNA expressions of CCL3, CCL4, and CXCL8 were up-regulated by IL-1ß and down-regulated by tacrolimus
Chiang et al., BMC veterinary research 2012 (Dog Diseases...) : Moreover, in P phase CTVT, while IL-1ß and TGF-ß had no obvious effect on CXCL7 expression, IL-6 was found significantly to reduce CXCL7 expression in a dose dependent manner
Rafferty et al., Cell Immunol 2012 : Suppressing ROCK with the Y27632 inhibitor suppressed IL-1 stimulated Caco-2 cell CXCL8/IL-8 and IEC-6 cell CCL2/MCP-1 secretion and mRNA levels