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CXCL12 — NAMPT

Text-mined interactions from Literome

Kanda et al., Endocrinology 2011 (Psoriasis) : Visfatin enhances CXCL8 , CXCL10, and CCL20 production in human keratinocytes ... Visfatin enhanced TNF-a induced CXC chemokine ligand ( CXCL ) 8, CXCL10 , and CC chemokine ligand (CCL) 20 secretion and mRNA expression in keratinocytes, although visfatin alone was ineffective ... A small interfering RNA against nuclear factor-?B ( NF-?B ) p65 suppressed the visfatin induced production of CXCL8 , CXCL10, and CCL20 whereas a small interfering RNA against signal transducer and activator of transcription ( STAT ) 3 suppressed CXCL8 induction ... These results suggest that visfatin enhances CXCL8 , CXCL10, and CCL20 production in human keratinocytes and homologous chemokine production in murine skin
Huang et al., J Cell Physiol 2013 (Colorectal Neoplasms...) : Visfatin induces stromal cell derived factor-1 expression by ß1 integrin signaling in colorectal cancer cells ... We found that visfatin stimulation led to an increase in the expression and secretion of SDF-1 in CRC DLD-1 and SW48 cells ... Experiments involving specific inhibitors and small interfering RNA demonstrated that the activation of ERK and p38 mitogen activated protein kinase ( MAPK ) pathways are critical for visfatin induced SDF-1 expression ... Inhibition of NF-?B and AP-1 activation blocked the visfatin induced expression and activity of the SDF-1 promoter ... The effect of visfatin on DLD-1 signaling and SDF-1 expression was mediated by ß1 integrin