◀ Back to MAPK10
MAP2K7 — MAPK10
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
MAPK10
→
MAP2K7
(increases, MAP2K7 Activity, MAPK10 Activity)
Lisnock et al., Biochemistry 2000*
Evidence: These data suggest that MKK7 was largely responsible for JNK3 alpha 1 activation and that a single threonine phosphorylation may be all that is needed for JNK3 alpha 1 to be active
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OpenBEL Selventa BEL large corpus:
MAPK10
→
MAP2K7
(directlyIncreases, MAPK10 Activity)
Fleming et al., Biochem J 2000*
Evidence: Here we report that MKK4 shows a striking preference for the tyrosine residue (Tyr-185), and MKK7 a striking preference for the threonine residue (Thr-183) in three SAPK1/JNK1 isoforms tested (JNK1 alpha 1, JNK2 alpha 2 and JNK3 alpha 1)
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OpenBEL Selventa BEL large corpus:
MAPK10
→
MAP2K7
(increases, MAPK10 Activity)
Lisnock et al., Biochemistry 2000*
Evidence: These data suggest that MKK7 was largely responsible for JNK3 alpha 1 activation and that a single threonine phosphorylation may be all that is needed for JNK3 alpha 1 to be active
-
OpenBEL Selventa BEL large corpus:
MAPK10
→
MAP2K7
(directlyIncreases, MAPK10 Activity)
Evidence: 10715136;15911620
-
BioCarta mapkinase signaling pathway:
MKK7/MEK4 (MAP2K7/MAP2K4)
→
JNK1/MAPK9/MAPK10 (MAPK10/MAPK8/MAPK9)
(modification, activates)
-
KEGG Protein processing in endoplasmic reticulum:
MAP2K7
→
MAPK10/MAPK8/MAPK9
(protein-protein, activation)
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KEGG Osteoclast differentiation:
MAP2K7
→
MAPK10/MAPK8/MAPK9
(protein-protein, activation)
-
KEGG Toll-like receptor signaling pathway:
MAP2K4/MAP2K7
→
MAPK10/MAPK8/MAPK9
(protein-protein, phosphorylation)
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KEGG Fc epsilon RI signaling pathway:
MAP2K4/MAP2K7
→
MAPK10/MAPK8/MAPK9
(protein-protein, activation)
-
KEGG Neurotrophin signaling pathway:
MAP2K7
→
MAPK10/MAPK8/MAPK9
(protein-protein, activation)
-
KEGG GnRH signaling pathway:
MAP2K4/MAP2K7
→
MAPK10/MAPK8/MAPK9
(protein-protein, activation)
-
KEGG MAPK signaling pathway:
MAP2K7
→
MAPK10/MAPK8/MAPK9
(protein-protein, phosphorylation)
-
KEGG Influenza A:
MAP2K4/MAP2K7
→
MAPK10/MAPK8/MAPK9
(protein-protein, activation)
-
KEGG ErbB signaling pathway:
MAP2K4/MAP2K7
→
MAPK10/MAPK8/MAPK9
(protein-protein, activation)
-
NCI Pathway Database FAS (CD95) signaling pathway:
MKK7 (MAP2K7)
→
JNK family-active (MAPK8/MAPK9/MAPK10)
(modification, activates)
Toyoshima et al., J Cell Biol 1997
Evidence: assay
-
NCI Pathway Database FAS (CD95) signaling pathway:
MKK7 (MAP2K7)
→
JNK family (MAPK8/MAPK9/MAPK10)
(modification, activates)
Toyoshima et al., J Cell Biol 1997
Evidence: assay
-
NCI Pathway Database PDGFR-beta signaling pathway:
MKK4-MKK7 (MAP2K7/MAP2K4)
→
JNK family (MAPK8/MAPK9/MAPK10)
(modification, activates)
Chiariello et al., Nat Cell Biol 2001, Zhao et al., J Exp Med 2001, Furstoss et al., EMBO J 2002, Iavarone et al., J Biol Chem 2003, Boureux et al., J Cell Sci 2005
Evidence: mutant phenotype, assay
-
Reactome Reaction:
MAPK10
→
MAP2K7
(reaction)
Sato et al., Nat Immunol 2005, Wang et al., Mol Cell Biol 2007*, Deacon et al., J Biol Chem 1997
-
WikiPathways Structural Pathway of Interleukin 1 (IL-1):
MAP2K7
→
MAPK8/MAPK9/MAPK10
(activation)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
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STRING interaction:
MAPK10
—
MAP2K7
(interaction, mapped from kegg_pathways)
-
STRING interaction:
MAPK10
—
MAP2K7
(interaction, mapped from kegg_pathways)
-
STRING interaction:
MAP2K7
—
MAPK10
(interaction, mapped from grid)
-
STRING interaction:
MAP2K7
—
MAPK10
(interaction, mapped from grid)
Text-mined interactions from Literome
Martel-Pelletier et al., Arthritis Rheum 1999
(Osteoarthritis) :
Within minutes, IL-17 induced the phosphorylation of
mitogen activated protein kinase kinase-1/2 ( MEK-1/2 ), -3/6 ( MKK-3/6 ), p44/42, p38, and inhibitor of nuclear factor kappaB ( I kappaB)-alpha, as well as the
activation of
mitogen activated protein kinase activated protein kinase-1 and -2 ( MAPKAPK-1 and -2 )
Tu et al., J Biomed Sci 2001
(Carcinoma, Hepatocellular) :
On the other hand, PD98059, a specific inhibitor of
mitogen activated protein kinase kinase ,
blocks TPA induced
MAPK activation but has no effect on TPA induced tyrosine phosphorylation
Huang et al., Biochem Biophys Res Commun 2003
:
MAP3Ks are components of a three tiered protein kinase pathway in which a MAP3K phosphorylates and activates a
mitogen activated protein kinase kinase ( MAP2K ), which in turn
activates a
mitogen activated protein kinase ( MAPK )
Huwiler et al., Br J Pharmacol 1994
:
2. Both nucleotides stimulate phosphorylation and
activation of
mitogen activated protein kinase and a biphasic phosphorylation of the up-stream
mitogen activated protein kinase kinase
Daum et al., FEBS Lett 1998
:
Pervanadate inhibits
mitogen activated protein kinase kinase-1 in a
p38MAPK dependent manner