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CASP2 — MDM2
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Bonini et al., J Neurosci Res 2004
:
The z-VAD-fmk-sensitive apoptotic response requires a
caspase dependent
MDM-2 degradation, leading to p53 mitochondrial targeting accompanied by cytochrome c release and nucleosomal fragmentation
Wang et al., Oncogene 2004
:
The
caspase inhibitor, Z-VAD-FMK,
blocked the decrease in
Mdm2 as well as the increase in p53 resulting from Survivin disruption, indicating that Survivin regulates Mdm2 at the post-translational level
Pikkarainen et al., J Biol Chem 2009
:
Finally, antisense oligonucleotide mediated reduction of H ( 2 ) O ( 2 ) -induced
Mdm2 expression
increased caspase 3 activation
Oliver et al., Mol Cell 2011
:
Caspase-2 mediated cleavage of
Mdm2 creates a p53 induced positive feedback loop
Xie et al., Cancer cell international 2013
:
The application of genistein,
MDM2 inhibitor and XIAP inhibitor to the recovering HeLa cells
caused persistent
caspase activity and enhanced cell death ... The application of genistein,
MDM2 inhibitor and XIAP inhibitor to the recovering HeLa cells
caused persistent
caspase activity and enhanced cell death