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GRAP2 — IL2
Text-mined interactions from Literome
Asada et al., J Exp Med 1999
:
Overexpression of wild-type
Grf40 in Jurkat cells
induced a significant increase of SLP-76 dependent interleukin (IL)-2 promoter and nuclear factor of activated T cell ( NF-AT ) activation upon T cell receptor ( TCR ) stimulation, whereas the COOH-terminal SH3 deleted Grf40 mutant lacked any recognizable increase in
IL-2 promoter activity
Ling et al., Crit Care Med 2002
:
In contrast to its effects on the janus kinase/STAT pathways,
interleukin-6 activation of MAP kinases ( extracellular signal regulated kinase-1, extracellular signal regulated kinase-2, and
p38 ) was unaffected by endotoxin
Yan et al., J Biol Chem 2002
:
This model probiotic also inhibits
activation of the pro-apoptotic
p38/mitogen activated protein kinase by tumor necrosis factor,
interleukin-1alpha , or gamma-interferon
Pestka et al., Toxicology 2005
:
Inhibition of
p38 attenuated DON induced upregulation of
IL-2 while all three MAPK inhibitors suppressed IL-8 upregulation
Rasheed et al., Arthritis Res Ther 2010
(Osteoarthritis) :
Pomegranate extract inhibits the
interleukin-1ß induced activation of MKK-3,
p38a-MAPK and transcription factor RUNX-2 in human osteoarthritis chondrocytes