Gene interactions and pathways from curated databases and text-mining

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AKT1 — PIK3CG

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Hehl et al., Biochem J 2001 : Expression of a constitutive active PI3Kgamma ( PI3Kgamma-CAAX ) induced GVBD and increased the levels of phosphorylated Akt/protein kinase B and mitogen activated protein kinase ( MAPK ) ... Expression of a constitutive active PI3Kgamma ( PI3Kgamma-CAAX ) induced GVBD and increased the levels of phosphorylated Akt/protein kinase B and mitogen activated protein kinase ( MAPK )
Curnock et al., J Immunol 2003 : Our results show that expression of either kinase-dead PI3Kgamma ( KD-PI3Kgamma ) or Deltap85 ( a construct unable to bind class I ( A ) p110alpha, -beta, or -delta ) leads to a partial inhibition of SDF-1 stimulated protein kinase B phosphorylation, but had no effect on SDF-1 induced phosphorylation of the mitogen activated protein kinase ERK1/2
Oudit et al., Circulation 2003 (Cardiomegaly...) : The lack of PI3Kgamma attenuated the activation of Akt/protein kinase B and extracellular signal regulated kinase 1/2 signaling pathways in cardiac myocytes in response to isoproterenol
Vecchione et al., J Exp Med 2005 (Hypertension) : Conversely, PI3Kgamma was necessary to activate protein kinase B/Akt , which, in turn, enhanced L-type Ca ( 2+ ) channel mediated extracellular Ca ( 2+ ) entry ... Conversely, PI3Kgamma was necessary to activate protein kinase B/Akt , which, in turn, enhanced L-type Ca ( 2+ ) channel mediated extracellular Ca ( 2+ ) entry
Kang et al., Proc Natl Acad Sci U S A 2006 (Cell Transformation, Neoplastic) : The p110delta isoform constitutively activates the Akt signaling pathway ; p110gamma activates Akt only in the presence of serum
Guillermet-Guibert et al., Proc Natl Acad Sci U S A 2008 : In macrophages, both p110beta and p110gamma contributed to Akt activation induced by the GPCR agonist complement 5a, but not by the Tyr kinase ligand colony stimulating factor-1
Canobbio et al., Blood 2009 : However, PI3Kbeta, but not PI3Kgamma , enzymatic activity was absolutely required for Akt phosphorylation, Rap1 activation, and platelet aggregation downstream of the immunoreceptor tyrosine based activation motif ( ITAM ) -bearing receptor glycoprotein VI (GPVI)
Haubner et al., PloS one 2010 (Myocardial Reperfusion Injury) : Mechanistically, PI3Kgamma is required for activation of the Reperfusion Injury Salvage Kinase ( RISK ) pathway ( AKT/ERK1/2 ) and regulates phospholamban phosphorylation in the acute injury response
Bondeva et al., Science 1998 : Phosphoinositide 3-kinases (PI3Ks) activate protein kinase PKB ( also termed Akt ), and PI3Kgamma activated by heterotrimeric guanosine triphosphate binding protein can stimulate mitogen activated protein kinase ( MAPK ) ... Membrane targeted PI3Kgamma constitutively produced phosphatidylinositol 3,4, 3,4,5-trisphosphate and activated PKB but not MAPK