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EGFR — TNK2

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: Complex of EGFR-TNK2 → EGFR (directlyIncreases, EGFR/TNK2 Activity) Shen et al., Mol Biol Cell 2007*
  Evidence: The interaction of ACK1 with EGFR was dependent on the kinase activity or tyrosine phosphorylation of EGFR.
• OpenBEL Selventa BEL large corpus: TNK2 → EGFR (increases, TNK2 Activity)
  Evidence: This is taken from supplemental table 2 from PMID 15951569 Cut-offs were 2.25 for increase and 0.5 for decrease LLID were found by converting from GI assession numbers in DAVID Spreadsheet is saved in the project folder for Cell Signaling Project # bduckworth

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: EGFR — TNK2 (physical association, affinity chromatography technology) Pao-Chun et al., J Biol Chem 2009*
• IRef Biogrid Interaction: EGFR — TNK2 (physical association, affinity chromatography technology) Shen et al., Mol Biol Cell 2007*
• IRef Biogrid Interaction: EGFR — TNK2 (physical association, affinity chromatography technology) Howlin et al., Breast Cancer Res 2008*
• IRef Biogrid Interaction: EGFR — TNK2 (physical association, affinity chromatography technology) Tong et al., J Proteome Res 2008
• IRef Biogrid Interaction: EGFR — TNK2 (physical association, affinity chromatography technology) Lin et al., Mol Cell Biol 2010*
• IRef Hprd Interaction: TNK2 — EGFR (in vivo) Manser et al., Nature 1993*, Satoh et al., FEBS Lett 1996*
• IRef Intact Interaction: Complex of 23 proteins (association, anti bait coimmunoprecipitation) Thelemann et al., Mol Cell Proteomics 2005
• IRef Intact Interaction: Complex of 70 proteins (association, anti bait coimmunoprecipitation) Thelemann et al., Mol Cell Proteomics 2005
• IRef Ophid Interaction: TNK2 — EGFR (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Shen et al., Mol Biol Cell 2007 : The interaction of ACK1 with EGFR was dependent on the kinase activity or tyrosine phosphorylation of EGFR ... Suppression of the expression of ACK1 by ACK-RNAi inhibited ligand induced degradation of EGFR upon EGF stimulation, suggesting that ACK1 plays an important role in regulation of EGFR degradation in cells ... Overexpression of the Uba domain-deletion mutant of ACK1 blocked the ligand dependent degradation of EGFR, suggesting that ACK1 regulates EGFR degradation via its Uba domain
Schoenherr et al., PLoS Genet 2012 (MAP Kinase Signaling System) : ACK1 is activated by epidermal growth factor (EGF) receptor signaling and functions to regulate EGF receptor turnover