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BCR — PI3

Text-mined interactions from Literome

Buhl et al., J Immunol 1999 (Calcium Signaling...) : In view of previous findings that CD19 is involved in BCR mediated phosphatidylinositol 3-kinase (PI3-K) activation , we assessed its role in Btk activation
Astoul et al., J Cell Biol 1999 : Membrane translocation of PKB and subsequent PKB activation are dependent on BCR activation of phosphatidylinositol 3-kinase (PI3K)
Gold et al., J Immunol 1999 : We have previously shown that the B cell Ag receptor (BCR) activates phosphatidylinositol (PI) 3-kinase ... Using an Ab that specifically recognizes the activated form of Akt that is phosphorylated on serine 473, we show that BCR engagement activates Akt in a PI 3-kinase dependent manner
Nieborowska-Skorska et al., Oncogene 2000 (Leukemia, Myeloid) : We show here that the defect in activation of PI-3k/Akt by BCR/ABL DeltaSH2 mutant ( SH2 domain deleted ) and of STAT5 by BCR/ABL DeltaSH3+DeltaSH2 mutant ( SH3 and SH2 domains deleted ) is not permanent and both Akt and STAT5 could be ` re-activated ' by in vitro culture
Gold et al., Immunol Rev 2000 : In this review, we discuss the role of phosphatidylinositol 3-kinase (PI3K) and Rap 1 in B-cell receptor (BCR) signaling
van der Kuip et al., Blood 2001 : Thus, cooperative activation of PI-3K/AKT by Bcr-Abl and integrins causes synergistic protection of Bcr-Abl+ cells from DNA damage induced apoptosis
Taguchi et al., Immunology 2004 : When pre-BCR was cross linked with anti-micro heavy-chain antibodies, significant phosphorylation of intracellular molecules, including Syk, Shc, ERK MAP kinase, and AKT, and an activation of Ras were observed without regard to deficiency of BLNK expression, suggesting that BLNK is not required for pre-BCR mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signalling
Ahn et al., Blood 2006 : Reduction of LIME expression by the introduction of siRNA resulted in the disruption of BCR mediated activation of MAPK, calcium flux, NF-AT, PI3K , and NF-kappaB
Marshall et al., Biochem Soc Trans 2007 : PI3Ks ( phosphoinositide 3-kinases ) play critical roles in BCR ( B-cell receptor ) signalling via the generation of 3-phosphoinositide second messengers
Harrison-Findik et al., Oncogene 1995 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : P210 BCR/abl tyrosine kinase induces tyrosine phosphorylation of Shc, and activation of p21ras and PI 3-Kinase
Jain et al., Blood 1996 : PI 3-kinase activation in BCR/abl transformed hematopoietic cells does not require interaction of p85 SH2 domains with p210 BCR/abl ... Despite lack of direct interaction with p85 SH2 domains, expression of ts p210 BCR/abl resulted in rapid, time dependent activation of total and membrane associated PI 3-kinase and increased PI 3-kinase activity in anti-P-tyr and anti-abl immunoprecipitates ... These data suggest that BCR/abl induced activation of PI 3-kinase in hematopoietic cells does not require binding of p85 SH2 domains to BCR/abl gene product and involves interaction with other tyrosine phosphorylated intermediate proteins