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IRS1 — VEGFA
Text-mined interactions from Literome
Senthil et al., Biochem J 2002
:
VEGF augmented tyrosine phosphorylation of
IRS-1 in kidney epithelial cells and rat heart endothelial cells in a time dependent manner ... In the epithelial cells, association of
IRS-1 with type 2 VEGF receptor was
promoted by
VEGF ...
VEGF also
increased association of
IRS-1 with the p85 regulatory subunit of phosphoinositide 3-kinase ( PI 3-kinase ), and PI 3-kinase activity in IRS-1 immunoprecipitates was increased in VEGF treated cells
Hos et al., Invest Ophthalmol Vis Sci 2011
:
In macrophages,
VEGF-A expression levels were also
inhibited by
IRS-1 blockade
Maeno et al., J Biol Chem 2012
(Metabolic Diseases) :
Thr-86 of p85/PI3K was identified to be phosphorylated by PKC activation and confirmed to affect
IRS1 mediated
activation of Akt/eNOS by insulin and
VEGF using a deletion mutant of the Thr-86 region of p85/PI3K
Yin et al., Biochim Biophys Acta 2013
(Cell Transformation, Neoplastic...) :
Forced expression of N-RAS and
IRS1 restored
VEGF expression via transcriptional activation