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GRAP2 — IL6
Text-mined interactions from Literome
Park et al., Hepatology 1999
:
Although both p38 and p44/p42 mitogen activated protein kinases ( MAPKs ) were constitutively present and active in cholangiocytes,
IL-6 increased p44/p42, but not
p38 MAPK activity
Zauberman et al., Oncogene 1999
(Carcinoma, Hepatocellular...) :
Thus, we present evidence for a
role of
p38 in
IL-6 induced functions and a possible cross-talk between this MAPK homologue and the STAT pathway
Chae et al., Bone 2001
(MAP Kinase Signaling System) :
The
p38 mitogen activated protein kinase pathway
regulates interleukin-6 synthesis in response to tumor necrosis factor in osteoblasts
Shigemoto-Mogami et al., J Neurochem 2001
:
However, the activation of
p38 was not
sufficient for the
IL-6 induction because 2'- and 3'-O- ( 4-benzoylbenzoyl ) ATP, an agonist to P2X7 receptors, failed to produce IL-6 despite the fact that it activated p38
Webb et al., J Dent Res 2002
(Osteosarcoma) :
Transfection of IL-6 full-length and 5-deletion gene promoter reporter constructs indicated that
p38 MAPK activation by TNF-alpha
enhanced IL-6 gene expression, and that the p38 MAPK-responsive region resided in the proximal 260-bp segment
Ling et al., Crit Care Med 2002
:
In contrast to its effects on the janus kinase/STAT pathways,
interleukin-6 activation of MAP kinases ( extracellular signal regulated kinase-1, extracellular signal regulated kinase-2, and
p38 ) was unaffected by endotoxin
Ahmed et al., J Leukoc Biol 2002
(MAP Kinase Signaling System) :
Inhibition of IL-6 signaling by IL-1 and protein synthesis inhibitors was dependent on the p38 stress kinase, and activation of
p38 secondary to inducible expression of MKK6 was
sufficient to inhibit
IL-6 signaling
Yan et al., J Biol Chem 2002
:
This model probiotic also inhibits
activation of the pro-apoptotic
p38/mitogen activated protein kinase by tumor necrosis factor,
interleukin-1alpha , or gamma-interferon
Guo et al., J Biol Chem 2003
(Inflammation) :
This strategy established the
requirement for
p38 activity for the lipopolysaccharide stimulated production of IL-10, IL-1beta, and
IL-6 by the monocytic cell WEHI 274 and the production of IL-6 and TNFalpha stimulated by ligation of the Fc-gamma receptor of the mast cell MC/9
Li et al., J Biol Chem 2005
(Arteriosclerosis...) :
However,
MKK3/p38 signaling was specifically involved in TNF-alpha induction, and Erk1/2 signaling was
required for
IL-6
Wada et al., Immunol Lett 2005
(Sarcoma, Synovial) :
A novel
p38 MAP kinase inhibitor, R-130823,
inhibited the release of
IL-6 , IL-8 and MMP-13 in a concentration dependent manner, but not that of IL-1beta or MMP-2
Kher et al., J Thorac Cardiovasc Surg 2005
(Reperfusion Injury) :
The kidney was analyzed for expression of tumor necrosis factor alpha, interleukin 1beta, and
interleukin 6 ( enzyme linked immunosorbent assay and reverse transcriptase-polymerase chain reaction ) and
activation of
p38 mitogen activated protein kinase, caspase 3, and caspase 8 ( Western blot )
Rakshit et al., J Bone Joint Surg Am 2006
(Osteolysis) :
Wear particle inhibition of
interleukin-6 specifically
involves the activation of
p38 mitogen activated protein kinase and is accompanied by substantial induction of SOCS3, an inhibitor of interleukin-6 signaling
Lee et al., Scand J Immunol 2006
(Tuberculosis) :
Further, the activation of
p38 mitogen activated protein kinase and extracellular signal regulated kinase was
required for the induction of TNF-alpha and
IL-6 by MTB12, as well as by the 30-kDa Ag
Nonn et al., Carcinogenesis 2007
:
We utilized the cytokines tumor necrosis factor-alpha (TNFalpha) and interleukin (IL)-1beta to increase
p38 dependent nuclear factor kappa-B (NFkappaB) activation and expression of pro-inflammatory genes cyclooxygenase-2 (COX-2),
IL-6 and IL-8 in normal prostatic epithelial cells
Scicchitano et al., Blood Cells Mol Dis 2008
(MAP Kinase Signaling System) :
In addition, these results suggest that
IL-6 , IL-11, GM-CSF, G-CSF and Activin A are similarly
regulated by
p38 and NF-kappaB and that the MEK1, JNK and PKC pathways appear to play a more limited role in modulating cytokine expression in HBMSC
Hiruma et al., Blood 2009
(Multiple Myeloma) :
Increased
interleukin-6 (IL-6) production by MM stromal cells was
p38 MAPK
dependent while increased vascular cell adhesion molecule-1 ( VCAM-1 ) expression was NF-kappaB dependent
Lee et al., Eur J Pain 2010
:
Peripheral nerve injury leading to neuropathic pain induces the upregulation of
interleukin (IL)-6 and microglial CX3CR1 expression, and
activation of
p38 mitogen activated protein kinase ( MAPK ) in the spinal cord
Rasheed et al., Arthritis Res Ther 2010
(Osteoarthritis) :
Pomegranate extract inhibits the
interleukin-1ß induced activation of MKK-3,
p38a-MAPK and transcription factor RUNX-2 in human osteoarthritis chondrocytes
Chen et al., Molecular vision 2011
:
Inhibition of
p38MAPK , phosphoinositide 3-kinase (PI3K)-Akt and nuclear factor-kappaB ( NF-?B ), with the inhibitors SB203580, LY294002 and pyrrolydine dithiocarbamate ( PDTC ) respectively,
reduced IL-17 ( 100 ng/ml ) mediated production of CXCL8, CCL2, and
IL-6 in a concentration dependent manner
Nasimian et al., Inflamm Res 2013
:
NF-kB, JNK,
p38 and ERK specific inhibitors significantly
reduced the production of TNF-a and
IL-6 in macrophages stimulated with palmitate and also PTP1B knockdown cells
Beyaert et al., EMBO J 1996
:
The
p38/RK mitogen activated protein kinase pathway
regulates interleukin-6 synthesis response to tumor necrosis factor
Bode et al., J Hepatol 1998
:
The data indicate a modulation of lipopolysaccharide induced interleukin-6 production by ambient osmolarity and an
involvement of both
p38 and the extracellular signal regulated kinases-1 and -2 in the stimulation of
interleukin-6 production by lipopolysaccharide