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IL6 — NUP43
Text-mined interactions from Literome
Park et al., Hepatology 1999
:
Although both p38 and p44/p42 mitogen activated protein kinases ( MAPKs ) were constitutively present and active in cholangiocytes,
IL-6 increased
p44/p42 , but not p38 MAPK activity
Kawamura et al., Bone 1999
:
These results strongly suggest that protein kinase C-dependent
p42/p44 MAP kinase activation is
involved in endothelin-1 induced
IL-6 synthesis in osteoblast-like cells
Tokuda et al., Cell Signal 1999
:
p42/p44 mitogen activated protein kinase activation is
involved in prostaglandin F2alpha induced
interleukin-6 synthesis in osteoblasts
Schumann et al., J Neurochem 1999
(Neuroblastoma) :
We also show
IL-6 induced phosphorylation of
p42/44 mitogen activated protein (MAP) kinase, providing evidence for MAP kinase pathway activation
Fasshauer et al., Biochem Biophys Res Commun 2004
:
Studies using pharmacological inhibitors suggested that the positive effects of GH and
IL-6 on MCP-1 synthesis are at least in part
mediated by janus kinase 2 and
p44/42 mitogen activated protein kinase
Kralisch et al., Am J Physiol Endocrinol Metab 2005
:
Moreover, inhibitor studies suggested that the negative effect of
IL-6 on visfatin expression is, at least in part,
mediated by
p44/42 mitogen activated protein kinase
Yasui et al., Cancer Res 2005
(Multiple Myeloma) :
Finally, it down-regulates
interleukin-6 induced phosphorylation of Akt, signal transducers and activators of transcription 3, and
p42/44 mitogen activated protein kinase ; insulin-like growth factor-I triggered Akt phosphorylation ; and tumor necrosis factor alpha induced IkappaBalpha and nuclear factor-kappaB p65 phosphorylation
Kwon et al., J Dermatol Sci 2007
(MAP Kinase Signaling System) :
Sphingosylphosphorylcholine induced
interleukin-6 production is
mediated by protein kinase C and
p42/44 extracellular signal regulated kinase in human dermal fibroblasts ... These results suggest that SPC induced
IL-6 production is
mediated by PKC dependent
p42/44 ERK activation in human dermal fibroblasts cultured in vitro
Suh et al., J Cell Physiol 2009
:
Furthermore,
IL-6 increased
p44/42 MAPKs phosphorylation and p44 and p42 MAPK-specific siRNA mixture blocked IL-6 induced increase of 2-DG uptake and GLUT-2 protein expression
Dohgu et al., Journal of neuroinflammation 2011
:
These results show that
p44/42 and p38 MAPK signaling pathways
mediate the LPS enhanced release of
IL-6 and GM-CSF
Daeipour et al., J Immunol 1993
:
Recombinant
IL-6 activates
p42 and p44 mitogen activated protein kinases in the IL-6 responsive B cell line, AF-10