Gene interactions and pathways from curated databases and text-mining

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IL6 — NUP43

Text-mined interactions from Literome

Park et al., Hepatology 1999 : Although both p38 and p44/p42 mitogen activated protein kinases ( MAPKs ) were constitutively present and active in cholangiocytes, IL-6 increased p44/p42 , but not p38 MAPK activity
Kawamura et al., Bone 1999 : These results strongly suggest that protein kinase C-dependent p42/p44 MAP kinase activation is involved in endothelin-1 induced IL-6 synthesis in osteoblast-like cells
Tokuda et al., Cell Signal 1999 : p42/p44 mitogen activated protein kinase activation is involved in prostaglandin F2alpha induced interleukin-6 synthesis in osteoblasts
Schumann et al., J Neurochem 1999 (Neuroblastoma) : We also show IL-6 induced phosphorylation of p42/44 mitogen activated protein (MAP) kinase, providing evidence for MAP kinase pathway activation
Fasshauer et al., Biochem Biophys Res Commun 2004 : Studies using pharmacological inhibitors suggested that the positive effects of GH and IL-6 on MCP-1 synthesis are at least in part mediated by janus kinase 2 and p44/42 mitogen activated protein kinase
Kralisch et al., Am J Physiol Endocrinol Metab 2005 : Moreover, inhibitor studies suggested that the negative effect of IL-6 on visfatin expression is, at least in part, mediated by p44/42 mitogen activated protein kinase
Yasui et al., Cancer Res 2005 (Multiple Myeloma) : Finally, it down-regulates interleukin-6 induced phosphorylation of Akt, signal transducers and activators of transcription 3, and p42/44 mitogen activated protein kinase ; insulin-like growth factor-I triggered Akt phosphorylation ; and tumor necrosis factor alpha induced IkappaBalpha and nuclear factor-kappaB p65 phosphorylation
Kwon et al., J Dermatol Sci 2007 (MAP Kinase Signaling System) : Sphingosylphosphorylcholine induced interleukin-6 production is mediated by protein kinase C and p42/44 extracellular signal regulated kinase in human dermal fibroblasts ... These results suggest that SPC induced IL-6 production is mediated by PKC dependent p42/44 ERK activation in human dermal fibroblasts cultured in vitro
Suh et al., J Cell Physiol 2009 : Furthermore, IL-6 increased p44/42 MAPKs phosphorylation and p44 and p42 MAPK-specific siRNA mixture blocked IL-6 induced increase of 2-DG uptake and GLUT-2 protein expression
Dohgu et al., Journal of neuroinflammation 2011 : These results show that p44/42 and p38 MAPK signaling pathways mediate the LPS enhanced release of IL-6 and GM-CSF
Daeipour et al., J Immunol 1993 : Recombinant IL-6 activates p42 and p44 mitogen activated protein kinases in the IL-6 responsive B cell line, AF-10