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APC — H2AFX

Text-mined interactions from Literome

Kouzmenko et al., Oncogene 2008 (Adenomatous Polyposis Coli) : APC knockdown with siRNA decreased the rate of DNA DSB induced S139 histone H2AX phosphorylation in cells expressing endogenous full-length APC, but not in colon cancer cells with its truncation mutants, whereas ectopic APC expression stimulated the H2AX phosphorylation regardless of the type of endogenous APC
Zhang et al., Oncol Rep 2010 (Carcinoma, Non-Small-Cell Lung...) : Notably, 0.6 µM APC almost completely blocked docetaxel induced ?-H2AX formation and apoptosis