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ETS1 — MMP9
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Westermarck et al., FASEB J 1999
(Neoplasm Invasiveness...) :
This review will summarize the current view on the role of MMPs in tumor growth, invasion, and survival, and focus on the
role of mitogen activated protein kinases and AP-1 and
ETS transcription factors in the regulation of
MMP gene expression during invasion process
Igarashi et al., Tohoku J Exp Med 2001
:
The transcription factor
ETS-1 expressed in endothelial cells ( ECs )
regulates angiogenesis by inducing MMP-1, MMP-3,
MMP-9 , u-PA and integrin beta3 in endothelial cells ( ECs )
Grimshaw et al., Cancer Res 2004
(Breast Neoplasms...) :
Furthermore, stimulation of macrophage/tumor cell cocultures with
ETs led to increased
matrix metalloproteinase (MMP)-2 and -9 production by macrophages and a marked increase in invasion of tumor cells
Okuducu et al., Histopathology 2006
(Meningeal Neoplasms...) :
Ets-1 may be
involved in the transcriptional regulation of MMP-2 and
MMP-9 as well as in the invasive process in meningiomas
Furlan et al., J Cell Physiol 2008
(Mammary Neoplasms, Animal...) :
Moreover,
Ets-1 concomitantly
triggered matrix metalloproteinases ( MMP ) expression and activation, thus contributing to cell scattering
Park et al., Biochem Biophys Res Commun 2008
(Breast Neoplasms) :
The expression of
matrix metalloproteinase ( MMP ) genes was
enhanced by the overexpression of
HER2/Ets-1
Heo et al., J Cell Physiol 2010
:
In addition,
MMP-10 transcription was
mediated by
Ets-1 but not ERP/NET/ELK3
Himelstein et al., Clin Exp Metastasis 1998
:
Together these findings suggest that
Ets and SP-1 are the central transcriptional
activators of
MMP-9 gene expression in fibroblasts specifically responding to tumor cell contact, and that promoter conformation may regulate MMP-9 expression