Gene interactions and pathways from curated databases and text-mining

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Text-mined interactions from Literome

Noguchi et al., Inflammation 1999 : IL-4 and IFN-gamma suppressed PGE2 production by IL-1beta stimulated PDL fibroblasts, but COX activity enhanced by IL-1beta treatment was significantly inhibited by IL-4, not by IFN-gamma
Hayashi et al., Cytokine 2000 : The regulatory effects of interferon (IFN)-gamma and IL-4 on IL-1beta induced COX , PLA(2)isoforms expression and terminal delayed PGE ( 2 ) generation were examined in three types of human fibroblasts
Murakami et al., Carcinogenesis 2002 (Adenocarcinoma...) : The combined lipopolysaccharide- and interferon-gamma stimulated protein expressions of inducible nitric oxide synthase and cyclooxygenase (COX)-2 , together with the release of tumor necrosis factor-alpha, in RAW 264.7 mouse macrophages were also markedly diminished
Yu et al., Biochim Biophys Acta 2002 : Reporter assays also demonstrated reduced IFN gamma stimulated transcriptional activity of the iNOS and COX2 promoters by CLA
Shibata et al., J Neurochem 2003 : SB203580 also suppressed expression of iNOS and cyclooxygenase-2 (COX-2) induced by IFN-gamma/LPS
Han et al., Life Sci 2004 : The studies showed that ABL not only inhibited LPS/IFN-gamma mediated nitric oxide ( NO ) production and inducible nitric synthase ( iNOS ) expression, but also decreased LPS/IFN-gamma induced prostaglandin E2 ( PGE2 ) production and cyclo-oxygenase-2 (COX-2) expression in a concentration dependent manner
Hanna et al., Am J Reprod Immunol 2004 (Obstetric Labor, Premature) : The aim of this study was to evaluate the effects of interferon (IFN)-gamma on the expression of Cyclooxygenase (COX)-2 and production of prostaglandin E ( 2 ) ( PGE ( 2 ) ) in the human placenta from term and preterm labor deliveries
Vila-del Sol et al., J Immunol 2005 : IFN-gamma induces cyclooxygenase (COX)-2 expression and PG production in mouse macrophage cells
Caruso et al., Endocrinology 2007 (Inflammation) : alpha-MSH ( 5 microm ) reduced the nitric oxide production and the expression of inducible nitric oxide synthase (iNOS) induced by bacterial lipopolysaccharide ( LPS, 1 microg/ml ) plus interferon-gamma ( IFN-gamma, 50 ng/ml ) in cultured astrocytes after 24 h. alpha-MSH also attenuated the stimulatory effect of LPS/IFN-gamma on prostaglandin E ( 2 ) release and cyclooxygenase-2 (COX-2) expression
Martin et al., Kidney Int 1994 : Interferon gamma , which did not induce prostaglandin synthesis or influence COX mRNA expression, augmented the expression of MHC antigens in RMC
Pang et al., Br J Pharmacol 1997 : 2. We studied the effects of IL-1 beta, TNF alpha and IFN gamma on the induction of two isoforms of cyclo-oxygenase and its relation to prostaglandin E2 ( PGE2 ) release and COX activity ( reflected by PGE2 synthesis from exogenous arachidonic acid ) in human cultured airway smooth muscle cells
Endo et al., Am J Respir Cell Mol Biol 1998 : Lipopolysaccharide (LPS) stimulated PGE2 synthesis and COX activity were suppressed significantly by IL-4, but were not affected significantly by IL-10, IL-13, or IFN-gamma