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CD40LG — TRAF6

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: Complex of CD40-TRAF6 → CD40LG (increases) Zirlik et al., Arterioscler Thromb Vasc Biol 2007*
  Evidence: Ligation of CD40 on ECs triggered its association with TRAF-1, -3, and -6 from 15 to 60 minutes through 16 hours (Figure 2A)
• OpenBEL Selventa BEL large corpus: TRAF6 → CD40LG (increases) Zirlik et al., Arterioscler Thromb Vasc Biol 2007*
  Evidence: Ligation of CD40 enhanced the total protein expression of TRAF-1, -2, -3, and -6, but not TRAF-5 in ECs.
• BioCarta cd40l signaling pathway: CD40/CD40L/TRAF3/TRAF6 complex (TRAF6-CD40-TRAF3-CD40LG) → TRAF6 (modification, collaborate)
• BioCarta cd40l signaling pathway: CD40/CD40L/TRAF3/TRAF6 complex (TRAF6-CD40-TRAF3-CD40LG) → CD40/CD40L complex (CD40-CD40LG) (modification, collaborate)
  
• BioCarta cd40l signaling pathway: CD40/CD40L/TRAF3/TRAF6 complex (TRAF6-CD40-TRAF3-CD40LG) → TRAF3 (modification, collaborate)
• BioCarta cd40l signaling pathway: TRAF6 → CD40/CD40L complex (CD40-CD40LG) (modification, collaborate)
  
• BioCarta cd40l signaling pathway: CD40/CD40L/TRAF3/TRAF6 complex (TRAF6-CD40-TRAF3-CD40LG) → MEKK1 (MAP3K1) (modification, activates)
• NCI Pathway Database CD40/CD40L signaling: TRAF6 (TRAF6) → CD40/CD40L (trimer)/TRAF2 (trimer) complex (CD40LG-CD40-TRAF2) (modification, collaborate)
  Davies et al., Mol Cell Biol 2005
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database CD40/CD40L signaling: PI3K Class I family/CBL-b complex (CBLB) → CD40/CD40L (trimer)/TRAF6 complex (CD40LG-CD40-TRAF6) (modification, collaborate)
  Arron et al., J Biol Chem 2001
  Evidence: physical interaction, other species
• NCI Pathway Database CD40/CD40L signaling: PI3K Class I family/CBL-b complex (CBLB) → CD40/CD40L (trimer)/TRAF6/PI3K Class I family/CBL-b complex (CD40LG-CD40-TRAF6-CBLB) (modification, collaborate)
  Arron et al., J Biol Chem 2001
  Evidence: physical interaction, other species
• NCI Pathway Database CD40/CD40L signaling: CD40/CD40L (trimer)/TRAF6 complex (CD40LG-CD40-TRAF6) → CD40/CD40L (trimer)/TRAF6/PI3K Class I family/CBL-b complex (CD40LG-CD40-TRAF6-CBLB) (modification, collaborate)
  Arron et al., J Biol Chem 2001
  Evidence: physical interaction, other species
• NCI Pathway Database CD40/CD40L signaling: p38alpha-beta (MAPK14/MAPK11) → CD40/CD40L (trimer)/TRAF6 complex (CD40LG-CD40-TRAF6) (modification, collaborate)
  Pullen et al., J Biol Chem 1999, Davies et al., Mol Cell Biol 2005
  Evidence: mutant phenotype, assay
• NCI Pathway Database CD40/CD40L signaling: CD40/CD40L (trimer) complex (CD40LG-CD40) → TRAF6 (TRAF6) (modification, collaborate) Pullen et al., J Biol Chem 1999, Ishida et al., J Biol Chem 1996*, Pullen et al., Biochemistry 1998
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database CD40/CD40L signaling: CD40/CD40L (trimer) complex (CD40LG-CD40) → CD40/CD40L (trimer)/TRAF6 complex (CD40LG-CD40-TRAF6) (modification, collaborate)
  Pullen et al., J Biol Chem 1999, Ishida et al., J Biol Chem 1996*, Pullen et al., Biochemistry 1998
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database CD40/CD40L signaling: TRAF6 (TRAF6) → CD40/CD40L (trimer)/TRAF6 complex (CD40LG-CD40-TRAF6) (modification, collaborate)
  Pullen et al., J Biol Chem 1999, Ishida et al., J Biol Chem 1996*, Pullen et al., Biochemistry 1998
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database CD40/CD40L signaling: CD40/CD40L (trimer)/TRAF6 complex (CD40LG-CD40-TRAF6) → CD40/CD40L (trimer)/TTRAP complex (CD40LG-CD40-TDP2) (modification, activates)
  Pype et al., J Biol Chem 2000, Davies et al., Mol Cell Biol 2005
  Evidence: mutant phenotype, assay