Madhyastha et al., Biochim Biophys Acta 2006
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C-pc induced uPA expression was completely inhibited by PKA inhibitor ( KT 5200 ), indicating the regulation is dependent on PKA pathway
Ziegler et al., J Biol Chem 1991
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We have utilized the tumor promoter 12-O-tetradecanoylphorbol 13-acetate ( TPA ) to down-regulate PKC, in order to test for an effect on the PKA mediated induction of the uPA gene expression