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FOS — STAT4

Pathways - manually collected, often from reviews:

• NCI Pathway Database Downstream signaling in naïve CD8+ T cells: JUN/FOS/NFAT1-c-4 complex (FOS-JUN-NFATC1_NFATC2_NFATC3) → STAT4 (dimer) complex (STAT4) (transcription, activates)
  Curtsinger et al., J Exp Med 2003, Curtsinger et al., J Immunol 2005, Teixeira et al., J Immunol 2005, Campbell et al., Transplantation 1996
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database IL12 signaling mediated by STAT4: STAT4 (dimer) complex (STAT4) → JUN/FOS/NFAT1-c-4 complex (FOS-JUN) (transcription, inhibits)
  Villarino et al., J Immunol 2006*
  Evidence: mutant phenotype, other species