Gene interactions and pathways from curated databases and text-mining

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FGF21 — PI3

Text-mined interactions from Literome

Donowitz et al., Ann N Y Acad Sci 2000 : PI 3-kinase was also involved in FGF stimulation of NHE3 expressed in fibroblasts
Hadari et al., Proc Natl Acad Sci U S A 2001 : Experiments with FRS2 alpha-deficient fibroblasts demonstrate that FRS2 alpha plays a critical role in FGF induced mitogen activated protein ( MAP ) kinase stimulation, phosphatidylinositol-3 (PI-3) kinase activation, chemotactic response, and cell proliferation
Kong et al., Eur J Pharmacol 2013 (Diabetes Mellitus) : The FGF21 effects were phosphoinositide 3-kinase (PI3K) dependent , and, unlike insulin, Akt independent