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IL17A — PI3
Text-mined interactions from Literome
Park et al., Eur Respir J 2010
(Asthma) :
Recent findings have indicated that
PI3Ks also
regulate the expression of
interleukin (IL)-17 , which has been recognised as an important cytokine involved in airway inflammation ... In the present study, we investigated a
role of
PI3Kd in the regulation of
IL-17 expression in allergic airway disease using a murine model of asthma
Roller et al., J Immunol 2012
(Dermatitis...) :
We also show that
PI3Kd and PI3K? inhibitors
reduced IFN-? production by human TCR?d T cells and
IL-17 and IFN-? production by PBMCs from psoriatic or healthy donors
Liu et al., Autophagy 2013
(Pulmonary Fibrosis) :
In
response to
IL17A stimulation,
PI3K was activated and resulted in phosphorylation of GSK3B at Ser9, which subsequently attenuated the interaction of GSK3B with BCL2