Gene interactions and pathways from curated databases and text-mining

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LPL — NPY

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: LPL → NPY (increases, NPY Activity)
    Evidence: TABLE 2 Endogenous Chemicals Affecting Energy Intake and Expenditure: Appetite Stimulants

Text-mined interactions from Literome

Blumenthal et al., Clin Genet 2002 (Obesity) : Given the stimulatory effect of NPY on adipocyte lipoprotein lipase (LPL) activity, and the lack of association of other polymorphisms with serum lipid levels, we hypothesize that this is a gain-in-function polymorphism
Elitsur et al., Neuropeptides 1994 : Moreover, exogenous IL1-beta partially restored NPY 's stimulatory effect on monocyte depleted LPL DNA synthesis
Zarjevski et al., Endocrinology 1993 (Obesity) : Under the ad libitum and pair feeding conditions, icv NPY stimulated glucose uptake as well as total lipoprotein lipase activity in white adipose tissue ; it resulted in an increase total activity of hepatic and white adipose tissue acetyl coenzyme-A-carboxylase