◀ Back to ABL1

ABL1 — CRKL

Pathways - manually collected, often from reviews:

• KEGG Pathways in cancer: ABL1/BCR → Complex of CBL-CBLB-CBLC-CRK-CRKL (protein-protein, activation)
  
• KEGG Chronic myeloid leukemia: ABL1/BCR → Complex of CBL-CBLB-CBLC-CRK-CRKL (protein-protein, activation)
  
• KEGG ErbB signaling pathway: CRK/CRKL → ABL1/ABL2 (protein-protein, activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: CRKL — ABL1 (direct interaction, two hybrid) Heaney et al., Blood 1997*
• IRef Biogrid Interaction: CRKL — ABL1 (physical association, affinity chromatography technology) Heaney et al., Blood 1997*
• IRef Biogrid Interaction: CRKL — ABL1 (direct interaction, pull down) Heaney et al., Blood 1997*
• IRef Biogrid Interaction: CRKL — ABL1 (direct interaction, two hybrid) Ren et al., Genes Dev 1994*
• IRef Biogrid Interaction: CRKL — ABL1 (physical association, affinity chromatography technology) Ren et al., Genes Dev 1994*
• IRef Biogrid Interaction: CRKL — ABL1 (physical association, affinity chromatography technology) Kyono et al., J Immunol 1998*
• IRef Biogrid Interaction: CRKL — ABL1 (direct interaction, pull down) Ren et al., Genes Dev 1994*
• IRef Biogrid Interaction: CRKL — ABL1 (physical association, affinity chromatography technology) Peterson et al., Immunity 2008*
• IRef Biogrid Interaction: CRKL — ABL1 (physical association, affinity chromatography technology) Johnson et al., PloS one 2009*
• IRef Biogrid Interaction: CRKL — ABL1 (physical association, affinity chromatography technology) Patel et al., Genes Chromosomes Cancer 2006*
• IRef Biogrid Interaction: CRKL — ABL1 (physical association, affinity chromatography technology) Ribon et al., Mol Cell Biol 1996
• IRef Biogrid Interaction: CRKL — ABL1 (physical association, affinity chromatography technology) Nishihara et al., Int J Hematol 2003*
• IRef Biogrid Interaction: CRKL — ABL1 (physical association, affinity chromatography technology) Senechal et al., Mol Cell Biol 1998*
• IRef Hprd Interaction: Complex of CBL-ABL1-CRKL-ABL1-CBL-CRKL-CRKL-ABL1-CBL (in vivo) Grossmann et al., FEBS Lett 2004
• IRef Hprd Interaction: Complex of 17 proteins (in vivo) Uemura et al., Leukemia 1997*
• IRef Hprd Interaction: CRKL — ABL1 (in vitro) Salgia et al., J Biol Chem 1995*, Heaney et al., Blood 1997*
• IRef Hprd Interaction: CRKL — ABL1 (in vivo) Salgia et al., J Biol Chem 1995*, Heaney et al., Blood 1997*
• IRef Intact Interaction: CRKL — ABL1 (physical association, anti bait coimmunoprecipitation) Gutiérrez-Berzal et al., Exp Cell Res 2006*
• IRef Intact Interaction: CRKL — ABL1 (physical association, pull down) Gutiérrez-Berzal et al., Exp Cell Res 2006*
• IRef Ophid Interaction: CRKL — ABL1 (aggregation, confirmational text mining) Salgia et al., J Biol Chem 1995*
• IRef Ophid Interaction: CRKL — ABL1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Rhodes et al., Exp Hematol 2000 : Additionally, in the presence of Bcr-Abl , CrkL is found in the nucleus, can be detected in a Stat5/DNA complex, and increases transcriptional activation from a Stat-responsive reporter construct
Heaney et al., Blood 1997 (Cell Transformation, Neoplastic) : Thus, a direct interaction of CRKL and BCR-ABL is not required for CRKL to become tyrosine phosphorylated by BCR-ABL and suggests that CRKL function may still be required for BCR-ABL function through an indirect interaction