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IL13 — IL2RG
Text-mined interactions from Literome
Doucet et al., Eur J Immunol 2002
(Inflammation) :
Here we show that in normal lung fibroblasts IL-4 and
IL-13 induce the expression of the gamma c chain and its association with Janus kinase (JAK) 3, while lung myofibroblasts constitutively express a
gamma c chain displaying a limited association with JAK3
Ginn et al., Hum Mutat 2004
(Genetic Diseases, X-Linked...) :
Atypical phenotypes have also been described, but relatively little is known about the mechanisms by which the underlying mutations impair
gammac dependent
interleukin receptor signalling to produce these disease variants
He et al., J Immunol 1995
(Cell Transformation, Neoplastic) :
The inability of m gamma or m gamma t expression to affect IL-13 induced proliferation by B9 indicates that
gamma c does not obviously
contribute to the
IL-13R and does not function as the shared subunit of the IL-4R and IL-13R
Obiri et al., J Biol Chem 1995
:
These data suggest that the interaction of
IL-13 with IL-4R does not
involve gamma c and IL-13R itself may be a novel subunit of the IL-4R
Obiri et al., J Biol Chem 1997
:
To better understand the
role of
gammac in
IL-13 binding and signaling, we have transfected a renal cell carcinoma cell line with gammac and examined IL-13 and IL-4 binding and signaling