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CCDC88A — TP53
Text-mined interactions from Literome
Robertson et al., Cancer Res 2001
(Carcinoma, Embryonal...) :
Moreover,
Ape1/ref-1 stimulates the DNA binding activity of transcription factors ( Fos-Jun, nuclear factor-kappaB, Myb, ATF/cyclic AMP-responsive element binding protein family, HIF-1alpha, HLF, PAX, and
p53 ) through a redox mechanism and thus represents a novel component of signal transduction processes that regulate eukaryotic gene expression
Achanta et al., Cancer Res 2004
:
Functional analysis showed that
p53 significantly
enhanced the sequential activities of hOGG1 and
APE in excising the 8-oxoG nucleotide from DNA in vitro
Seemann et al., Oncogene 2005
(Breast Neoplasms) :
Roles of thioredoxin reductase 1 and
APE/Ref-1 in the control of basal
p53 stability and activity ... To evaluate the
role of TRR and
APE/Ref-1 in
p53 regulation, we have abrogated their expression using RNA interference in cell lines expressing wild-type p53 ... However, inhibition of either TRR or
APE/Ref-1 did not
prevent activation and accumulation of
p53 in response to DNA-damage by doxorubicin
Zaky et al., Nucleic Acids Res 2008
:
Taken together, our results demonstrate that WTp53 is a negative regulator of APE1 expression, so that
repression of
APE1 by
p53 could provide an additional pathway for p53 dependent induction of apoptosis in response to DNA damage
Unnikrishnan et al., Free Radic Biol Med 2009
:
In addition, loss of
APE1/Ref-1 increases the apoptotic response to oxidative stress, in which significant increases in GADD45g expression,
p53 protein stability, and caspase activity are observed
Bhattacharyya et al., Gastroenterology 2009
(Helicobacter Infections) :
Apurinic/apyrimidinic endonuclease-1 ( APE-1 ) regulates transcriptional activity of
p53 , and H pylori induce APE-1 expression in human GECs
Hamann et al., Mutat Res 2012
:
We present evidence that
p53 is not
essential for hOGG1 and APE1 gene expression as well as OGG and
APE activity in unstressed HCT116 cells ; however, it plays an important role in the cellular response to cadmium treatment
Cun et al., PloS one 2013
(Carcinoma, Hepatocellular...) :
APE1 was strongly expressed in MHCC97L cells and was induced by irradiation in a dose dependent manner, and Ad5/F35-siAPE1 effectively
inhibited irradiation induced APE1 and
p53 expression
Sengupta et al., PloS one 2013
:
Moreover, ectopic
p53 in p53-null cells
inhibited AP4 's association with
APE1 , their binding to the promoter and p21 repression