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KDM1A — TP53
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
KDM1A
—
TP53
(physical association, affinity chromatography technology)
Tsai et al., Mol Cell Biol 2008*
-
IRef Biogrid Interaction:
KDM1A
—
TP53
(direct interaction, pull down)
Tsai et al., Mol Cell Biol 2008*
-
IRef Biogrid Interaction:
KDM1A
—
TP53
(direct interaction, enzymatic study)
Huang et al., Nature 2007*
-
IRef Biogrid Interaction:
KDM1A
—
TP53
(direct interaction, pull down)
Huang et al., Nature 2007*
-
IRef Biogrid Interaction:
KDM1A
—
TP53
(physical association, affinity chromatography technology)
Huang et al., Nature 2007*
-
IRef Intact Interaction:
Complex of 29 proteins
(association, anti tag coimmunoprecipitation)
Coffill et al., EMBO Rep 2012
Text-mined interactions from Literome
Huang et al., Nature 2007
:
p53 is
regulated by the lysine demethylase
LSD1
Sareddy et al., Oncotarget 2013
(Brain Neoplasms...) :
Inhibition of
KDM1 promoted up regulation of the
p53 target genes p21 and PUMA ... Inhibition of
KDM1 increased levels of H3K4-me2 and H3K9-Ac histone modifications, reduced H3K9-me2 modification and
promoted expression of
p53 target genes ( p21 and PUMA ), leading to apoptosis of glioma xenograft tumors