◀ Back to NOTCH1
APH1B — NOTCH1
Pathways - manually collected, often from reviews:
-
NCI Pathway Database Notch signaling pathway:
NOTCH1 heterodimer/DNER complex (NOTCH1-DNER)
→
Gamma Secretase complex (PSEN1-NCSTN-APH1A-PSENEN-APH1B)
(modification, collaborate)
De Strooper et al., Nature 1999, Ray et al., J Biol Chem 1999, Mumm et al., Mol Cell 2000, Mizutani et al., Proc Natl Acad Sci U S A 2001, Saxena et al., J Biol Chem 2001, Lee et al., J Biol Chem 2002, Schroeter et al., Proc Natl Acad Sci U S A 2003, Fraering et al., Biochemistry 2004, Eiraku et al., Nat Neurosci 2005, Kopan et al., Proc Natl Acad Sci U S A 1996, Schroeter et al., Nature 1998
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Notch signaling pathway:
Gamma Secretase complex (PSEN1-NCSTN-APH1A-PSENEN-APH1B)
→
NICD (NOTCH1)
(modification, activates)
De Strooper et al., Nature 1999, Ray et al., J Biol Chem 1999, Mumm et al., Mol Cell 2000, Mizutani et al., Proc Natl Acad Sci U S A 2001, Saxena et al., J Biol Chem 2001, Lee et al., J Biol Chem 2002, Schroeter et al., Proc Natl Acad Sci U S A 2003, Fraering et al., Biochemistry 2004, Eiraku et al., Nat Neurosci 2005, Kopan et al., Proc Natl Acad Sci U S A 1996, Schroeter et al., Nature 1998
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Notch signaling pathway:
NOTCH1 heterodimer/NB-3 complex (NOTCH1-CNTN6)
→
Gamma Secretase complex (PSEN1-NCSTN-APH1A-PSENEN-APH1B)
(modification, collaborate)
De Strooper et al., Nature 1999, Ray et al., J Biol Chem 1999, Mumm et al., Mol Cell 2000, Mizutani et al., Proc Natl Acad Sci U S A 2001, Saxena et al., J Biol Chem 2001, Lee et al., J Biol Chem 2002, Schroeter et al., Proc Natl Acad Sci U S A 2003, Cui et al., J Biol Chem 2004, Fraering et al., Biochemistry 2004, Kopan et al., Proc Natl Acad Sci U S A 1996, Schroeter et al., Nature 1998
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Notch signaling pathway:
Gamma Secretase complex (PSEN1-NCSTN-APH1A-PSENEN-APH1B)
→
NICD (NOTCH1)
(modification, activates)
De Strooper et al., Nature 1999, Ray et al., J Biol Chem 1999, Mumm et al., Mol Cell 2000, Mizutani et al., Proc Natl Acad Sci U S A 2001, Saxena et al., J Biol Chem 2001, Lee et al., J Biol Chem 2002, Schroeter et al., Proc Natl Acad Sci U S A 2003, Cui et al., J Biol Chem 2004, Fraering et al., Biochemistry 2004, Kopan et al., Proc Natl Acad Sci U S A 1996, Schroeter et al., Nature 1998
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Presenilin action in Notch and Wnt signaling:
NEXT (NOTCH1)
→
Gamma Secretase complex (PSEN1-NCSTN-APH1A-PSENEN-APH1B)
(modification, collaborate)
Mumm et al., Mol Cell 2000
Evidence: assay, other species
-
NCI Pathway Database Presenilin action in Notch and Wnt signaling:
Gamma Secretase complex (PSEN1-NCSTN-APH1A-PSENEN-APH1B)
→
NICD (NOTCH1)
(modification, activates)
Mumm et al., Mol Cell 2000
Evidence: assay, other species
-
NCI Pathway Database Notch signaling pathway:
NOTCH1 heterodimer/CNTN1 complex (NOTCH1-CNTN1)
→
Gamma Secretase complex (PSEN1-NCSTN-APH1A-PSENEN-APH1B)
(modification, collaborate)
De Strooper et al., Nature 1999, Ray et al., J Biol Chem 1999, Mumm et al., Mol Cell 2000, Mizutani et al., Proc Natl Acad Sci U S A 2001, Saxena et al., J Biol Chem 2001, Lee et al., J Biol Chem 2002, Schroeter et al., Proc Natl Acad Sci U S A 2003, Hu et al., Cell 2003, Fraering et al., Biochemistry 2004, Kopan et al., Proc Natl Acad Sci U S A 1996, Schroeter et al., Nature 1998
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Notch signaling pathway:
Gamma Secretase complex (PSEN1-NCSTN-APH1A-PSENEN-APH1B)
→
NICD (NOTCH1)
(modification, activates)
De Strooper et al., Nature 1999, Ray et al., J Biol Chem 1999, Mumm et al., Mol Cell 2000, Mizutani et al., Proc Natl Acad Sci U S A 2001, Saxena et al., J Biol Chem 2001, Lee et al., J Biol Chem 2002, Schroeter et al., Proc Natl Acad Sci U S A 2003, Hu et al., Cell 2003, Fraering et al., Biochemistry 2004, Kopan et al., Proc Natl Acad Sci U S A 1996, Schroeter et al., Nature 1998
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Notch signaling pathway:
NEXT (NOTCH1)
→
Gamma Secretase complex (PSEN1-NCSTN-APH1A-PSENEN-APH1B)
(modification, collaborate)
De Strooper et al., Nature 1999, Ray et al., J Biol Chem 1999, Mumm et al., Mol Cell 2000, Mizutani et al., Proc Natl Acad Sci U S A 2001, Saxena et al., J Biol Chem 2001, Lee et al., J Biol Chem 2002, Schroeter et al., Proc Natl Acad Sci U S A 2003, Fraering et al., Biochemistry 2004, Kopan et al., Proc Natl Acad Sci U S A 1996, Schroeter et al., Nature 1998
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Notch signaling pathway:
Gamma Secretase complex (PSEN1-NCSTN-APH1A-PSENEN-APH1B)
→
NICD (NOTCH1)
(modification, activates)
De Strooper et al., Nature 1999, Ray et al., J Biol Chem 1999, Mumm et al., Mol Cell 2000, Mizutani et al., Proc Natl Acad Sci U S A 2001, Saxena et al., J Biol Chem 2001, Lee et al., J Biol Chem 2002, Schroeter et al., Proc Natl Acad Sci U S A 2003, Fraering et al., Biochemistry 2004, Kopan et al., Proc Natl Acad Sci U S A 1996, Schroeter et al., Nature 1998
Evidence: mutant phenotype, assay, physical interaction
-
Reactome Reaction:
NOTCH1
→
APH1B
(reaction)
De Strooper et al., Nature 1999, Huppert et al., Nature 2000*, Fortini et al., Nat Rev Mol Cell Biol 2002, Rustighi et al., Nat Cell Biol 2009*, Schroeter et al., Nature 1998
-
WikiPathways Notch Signaling Pathway:
APH1A/APH1B/TNF/PSEN1/PSEN2/NCSTN
→
NOTCH2/NOTCH3/NOTCH4/NOTCH1
(activation)
Text-mined interactions from Literome
Mumm et al., Mol Cell 2000
:
Gamma-secretase-like proteolysis at site 3 ( S3 ), within the transmembrane domain, releases the Notch intracellular domain ( NICD ) and
activates CSL mediated
Notch signaling
Curry et al., Oncogene 2005
(Sarcoma, Kaposi) :
Gamma secretase inhibitor
blocks Notch activation and induces apoptosis in Kaposi 's sarcoma tumor cells
Koyanagi et al., Circ Res 2007
:
Gamma-secretase dependent
Notch activation is required for cardiac gene expression in human cells and induces the expression of noncanonical Wnt proteins, which may act in a paracrine manner to further amplify cardiac differentiation
Real et al., Nat Med 2009
(Precursor T-Cell Lymphoblastic Leukemia-Lymphoma) :
Gamma-secretase inhibitors (GSIs) block the activation of the oncogenic protein
Notch homolog-1 (NOTCH1) in T cell acute lymphoblastic leukemia ( T-ALL )
Shimoyama et al., Arterioscler Thromb Vasc Biol 2010
(Diabetes Mellitus, Experimental...) :
Gamma secretase inhibitor, an
inhibitor of
Notch signaling, partially inhibited the enhanced expression of p21 induced by CCN3