◀ Back to HRAS
HRAS — RASGRF2
Pathways - manually collected, often from reviews:
-
KEGG MAPK signaling pathway:
RASGRF1/RASGRF2
→
HRAS/KRAS/MRAS/NRAS/RRAS/RRAS2
(protein-protein, activation)
-
NCI Pathway Database Regulation of Ras family activation:
RASGRF2 (RASGRF2)
→
HRAS/GDP complex (HRAS)
(modification, activates)
Anborgh et al., Mol Cell Biol 1999, Mattingly et al., J Biol Chem 1999*, Gotoh et al., J Biol Chem 2001*, Yang et al., J Biol Chem 2003*, Arozarena et al., Mol Cell Biol 2004*, Farnsworth et al., Nature 1995*, Schweighoffer et al., Oncogene 1993*, Wei et al., Gene 1994*
Evidence: assay
-
Reactome Reaction:
HRAS
→
RASGRF2
(reaction)
Krapivinsky et al., Neuron 2003
Text-mined interactions from Literome
Gotoh et al., J Biol Chem 2001
:
Here we show that whereas
Ras-GRF1 activated both
Ha-Ras and R-Ras in cells, Ras-GRF2 activated only Ha-Ras
Arozarena et al., Mol Cell Biol 2004
:
With the aid of H-Ras constructs specifically tethered to the plasma membrane, endoplasmic reticulum, and Golgi complex, we demonstrate that RasGRF1 and
RasGRF2 can
activate plasma membrane and reticular, but not Golgi associated,
H-Ras
Yang et al., Mol Biol Cell 2006
:
These results suggest that coordinated
activation of
H-Ras and Rac1 by
Ras-GRF1 may be a significant controller of neuronal cell size
Zhu et al., J Biol Chem 2007
(MAP Kinase Signaling System...) :
Experimental evidence indicated that this phenomenon was associated with destabilization and ubiquitylation of
Ras-GRF1 , a guanine nucleotide exchange factor that
activates H-Ras by facilitating the release of GDP
Jones et al., J Biol Chem 1998
:
We found that
Ras-GRF/Cdc25Mm activates
Ha-Ras , but does not activate N-Ras or K-Ras 4B, protein in vivo