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CCL2 — ITIH4

Text-mined interactions from Literome

Fantuzzi et al., Blood 2008 (HIV Infections) : Notably, PC-PLC activation through CCR5 is specifically induced by gp120 , since triggering CCR5 through its natural ligand CCL4 ( MIP-1beta ) does not affect PC-PLC cellular distribution and enzymatic activity, as well as CCL2 secretion, thus suggesting that different signaling pathways can be activated through CCR5 interaction with HIV-1 or chemokine ligands
Bruno et al., Gut 2010 (HIV Infections...) : gp120 also resulted in a significant increase in secretion ( 1.5+/-0.3-fold, p=0.03 ) and gene expression ( 1.47+/-0.13-fold, p=0.02 ) of the proinflammatory chemokine monocyte chemoattractant protein-1 , and in increased gene expression of tissue inhibitor of metalloprotease-1 and interleukin-6 ( 2.03+/-0.57-fold, p=0.02 )
Spadaro et al., PloS one 2013 : HIV-1 envelope glycoprotein gp120 induces , independently of infection, the release of CCL2 from macrophages ... Notably, phosphatidylcholine-specific phospholipase C ( PC-PLC ), previously reported to be required for NF-kB mediated CCL2 production induced by gp120 in macrophages, drives both ERK1/2 activation and PI-PLC ß1 nuclear localization induced by gp120 ... The finding that a concerted gp120 mediated signaling involving both PC- and PI-specific PLCs is required for the expression of CCL2 in macrophages suggests that this signal transduction pathway may also be relevant for the modulation of viral replication in these cells