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E2F5 — MYLIP
Text-mined interactions from Literome
Aguda et al., Proc Natl Acad Sci U S A 2008
(Neoplasms) :
In return,
E2F and Myc
induce the transcription of
miR-17-92 , thus forming a negative feedback loop in the interaction network
Dar et al., J Biol Chem 2011
(Melanoma...) :
Overexpression of
miR-205 in melanoma cells
reduced E2F1 and
E2F5 protein levels
Bomben et al., Leukemia 2012
(Leukemia, Lymphocytic, Chronic, B-Cell) :
The enforced expression of
miR-17 , a major member from this family,
reduced the expression of the tumor suppressor genes
E2F5 , TP53INP1, TRIM8 and ZBTB4, and protected cells from serum-free induced apoptosis ( P = 0.05 )
Noguchi et al., J Biol Chem 2012
(Melanoma) :
The ectopic expression of
miR-203 in melanoma cells
reduced the levels of E2F3a,
E2F3b , and ZBP-89 protein expression
Yan et al., PloS one 2012
:
In turn,
E2F is
inhibited by
miR449 through regulating different transcripts, thus forming negative feedback loops in the interaction network