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LIMK1 — PAK1

Pathways - manually collected, often from reviews:

• KEGG Axon guidance: PAK1/PAK2/PAK3/PAK4/PAK6/PAK7 → LIMK1/LIMK2 (protein-protein, activation)
• KEGG Fc gamma R-mediated phagocytosis: PAK1 → LIMK1/LIMK2 (protein-protein, activation)
• KEGG Regulation of actin cytoskeleton: PAK1/PAK2/PAK3/PAK4/PAK6/PAK7 → LIMK1/LIMK2 (protein-protein, phosphorylation)
• Reactome Reaction: LIMK1 → PAK1 (reaction) Edwards et al., Nat Cell Biol 1999, Aizawa et al., Nat Neurosci 2001
• WikiPathways Regulation of Actin Cytoskeleton: PAK1/PAK2/PAK3/PAK4/PAK6/PAK7 → LIMK1 (activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: LIMK1 — PAK1 (physical association, affinity chromatography technology) Edwards et al., Nat Cell Biol 1999
• IRef Biogrid Interaction: LIMK1 — PAK1 (direct interaction, pull down) Edwards et al., Nat Cell Biol 1999
• IRef Hprd Interaction: LIMK1 — PAK1 (in vitro) Edwards et al., Nat Cell Biol 1999, Ohashi et al., J Biol Chem 2000*, Sumi et al., J Biol Chem 2001*
• IRef Hprd Interaction: LIMK1 — PAK1 (in vivo) Edwards et al., Nat Cell Biol 1999, Ohashi et al., J Biol Chem 2000*, Sumi et al., J Biol Chem 2001*
• IRef Intact Interaction: PAK1 — LIMK1 (phosphorylation reaction, protein kinase assay) Edwards et al., Nat Cell Biol 1999
• IRef Intact Interaction: PAK1 — LIMK1 (colocalization, fluorescence microscopy) Edwards et al., Nat Cell Biol 1999
• IRef Intact Interaction: PAK1 — LIMK1 (physical association, anti bait coimmunoprecipitation) Edwards et al., Nat Cell Biol 1999
• IRef Intact Interaction: PAK1 — LIMK1 (physical association, pull down) Edwards et al., Nat Cell Biol 1999
• IRef Ophid Interaction: PAK1 — LIMK1 (aggregation, confirmational text mining) Edwards et al., Nat Cell Biol 1999
• IRef Ophid Interaction: PAK1 — LIMK1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Sumi et al., J Biol Chem 2001 : Together with the finding that LIMK1 is regulated by Pak1 , LIMK1 and LIMK2 are regulated by different protein kinases downstream of distinct Rho family GTPases
Sumi et al., J Biol Chem 2001 : Pak1 and ROCK, respectively, activate LIMK1 and LIMK2 downstream of Rac and Rho ; however, an effector protein kinase for LIMKs downstream of Cdc42 remains to be defined
Thirone et al., Am J Physiol Cell Physiol 2009 : Hyperosmolarity provoked cofilin phosphorylation was mediated by the Rho/Rho kinase ( ROCK ) /LIM kinase ( LIMK ) but not the Rac/PAK/LIMK pathway, because 1 ) dominant negative ( DN ) Rho and DN-ROCK but not DN-Rac and DN-PAK inhibited cofilin phosphorylation ; 2 ) constitutively active ( CA ) Rho and CA-ROCK but not CA-Rac and CA-PAK induced cofilin phosphorylation ; 3 ) hyperosmolarity induced LIMK-2 phosphorylation, and 4 ) inhibition of ROCK by Y-27632 suppressed the hypertonicity triggered LIMK-2 and cofilin phosphorylation.We thenexamined whether cofilin and its phosphorylation play a role in the hypertonicity triggered F-actin changes
Ho et al., Pigment Cell Melanoma Res 2013 (Melanoma...) : Molecular studies revealed that RHOJ alters actin cytoskeletal dynamics by inducing the phosphorylation of LIMK , cofilin, and p41-ARC ( ARP2/3 complex subunit ) in a PAK1 dependent manner in vitro and in tumor xenografts