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FGF2 — NUP43
Text-mined interactions from Literome
Hata et al., Diabetes 1999
:
Basic fibroblast growth factor induces expression of VEGF receptor KDR through a protein kinase C and
p44/p42 mitogen activated protein kinase dependent pathway
Beer et al., J Biol Chem 2000
:
Despite their apparently similar but low affinities,
FGF-10 but not FGF-7
induced the activation of
p44/42 mitogen activated protein kinase in FGFR1-IIIb expressing L6 myoblasts and stimulated mitogenesis in these cells, demonstrating that this new receptor variant is a functional transmembrane receptor for FGF-10
Zhang et al., Hypertens Res 2000
:
1 ) bFGF ( 20 ng/ml ) significantly activated p42/p44 MAPKs with a peak time of 5-15 min, which was maintained for 3 h. PD98059 ( 100 nM-10 microM ), a specific inhibitor of MAPK kinase, inhibited
bFGF induced
p42/p44 MAPKs
activation in a dose dependent manner ... Amlodipine, which could inhibit bFGF induced human VSMC proliferation, inhibited both short-term and sustained
p42/p44 MAPKs
activation by
bFGF , suggesting that bFGF induced VSMC proliferation may be related to p42/p44 MAPKs activation, and that the antiproliferative effect of amlodipine may be related to its inhibition of p42/p44 MAPKs activation
Delehedde et al., Biochem J 2002
:
Fibroblast growth factor-2 binds to small heparin derived oligosaccharides and
stimulates a sustained phosphorylation of
p42/44 mitogen activated protein kinase and proliferation of rat mammary fibroblasts
Fu et al., World J Gastroenterol 2003
(Reperfusion Injury) :
Intestinal I/R injury induced the expression of
p42/p44 MAPK, p38 MAPK, and SAPK/JNK pathways and exogenous
bFGF stimulated the early activation of p42/p44 MAPK and p38 MAPK pathways
Ghiselli et al., Arterioscler Thromb Vasc Biol 2003
:
FGF mediated phosphorylation of
p42/p44 mitogen activated protein kinase ( MAPK ) c-Raf, MAP kinase kinase kinase, MEK1/2 MAP kinase, kinase, stress activated protein kinase/c-Jun-NH2-terminal kinase, and p38 MAPK were variably reduced by ethanol
Chaturvedi et al., Endocrinology 2005
:
In both of these cell populations,
bFGF also
increased phosphorylation of MAPK
p44/42 ... U0126, an inhibitor of MAPK p44/42, blocked the
bFGF induced activation of MAPK
p44/42 as well as the bFGF induced cell proliferation of enriched lactotropes and PR1 cells ... Treatment of PR1 cells with bFGF increased the activity of Ras p21, whereas overexpression of a dominant negative mutant of Ras p21 abrogated the
bFGF induced
activation of MAPK
p44/42 in these cells ... Furthermore, the Src kinase inhibitor PP1 suppressed
bFGF induced
activation of MAPK
p44/42 in both enriched lactotropes and PR1 cells ... On the other hand, the
bFGF induced
activation of MAPK
p44/42 in enriched lactotropes and PR1 cells was not affected by protein kinase C inhibitors ... These data suggest that
bFGF induction of lactotropic cell proliferation is possibly
mediated by activation of Src kinase, Ras p21, and MAPK
p44/42
Yasuda et al., Biochem Biophys Res Commun 2005
:
We previously reported that
basic fibroblast growth factor ( FGF-2 )
activates stress activated protein kinase/c-Jun N-terminal kinase ( SAPK/JNK ) and
p44/p42 mitogen activated protein ( MAP ) kinase resulting in the stimulation of vascular endothelial growth factor ( VEGF ) release in osteoblast-like MC3T3-E1 cells and that FGF-2 activated p38 MAP kinase negatively regulates the VEGF release
Pan et al., J Pharmacol Exp Ther 2005
(Neoplasms...) :
YC-1 inhibited VEGF- and
bFGF induced
p42/p44 mitogen activated protein kinase and Akt phosphorylation as well as protein kinase C alpha translocation using Western blot analysis
Chaturvedi et al., J Pharmacol Exp Ther 2005
(MAP Kinase Signaling System) :
Role of protein kinase C-Ras-MAPK
p44/42 in ethanol and transforming growth factor-beta3 induced
basic fibroblast growth factor release from folliculostellate cells
Hanai et al., Life Sci 2006
:
We previously reported that
basic fibroblast growth factor ( FGF-2 )
activates stress activated protein kinase/c-Jun N-terminal kinase ( SAPK/JNK ) and
p44/p42 mitogen activated protein ( MAP ) kinase resulting in the stimulation of vascular endothelial growth factor ( VEGF ) release in osteoblast-like MC3T3-E1 cells
Takai et al., Mol Cell Endocrinol 2007
:
We previously reported that
basic fibroblast growth factor ( FGF-2 )
activates stress activated protein kinase/c-Jun N-terminal kinase ( SAPK/JNK ) and
p44/p42 mitogen activated protein ( MAP ) kinase, resulting in the release of vascular endothelial growth factor ( VEGF ) in osteoblast-like MC3T3-E1 cells
Seo et al., Microvasc Res 2008
(MAP Kinase Signaling System) :
We also show that TIMP-2 inhibition of
FGF-2 induced
p42/44(MAPK) activation and cell proliferation is associated with TIMP-2 binding to integrin alpha3beta1 on endothelial cell surfaces, as demonstrated by use of anti-integrin alpha3 or beta1 blocking antibodies, or disruption of integrin alpha3 expression by siRNA
Sa et al., J Biol Chem 1995
:
Activation of cytosolic phospholipase A2 by
basic fibroblast growth factor via a
p42 mitogen activated protein kinase dependent phosphorylation pathway in endothelial cells