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LPA — RELA
Text-mined interactions from Literome
Ediger et al., Eur Respir J 2003
(Cell Transformation, Neoplastic...) :
In contrast, nuclear factor (NF)-kappaB was activated by
LPA but not EGF and
NF-kappaB activation was completely
blocked only when Rho was inhibited
Fang et al., J Biol Chem 2004
(Ovarian Neoplasms) :
The optimal response of the IL-8 gene promoter to LPA relied on binding sites for
NF-kappaB and AP-1, two transcription factors that were strongly
activated by
LPA in ovarian cancer cell lines
Cummings et al., J Biol Chem 2004
(Inflammation) :
Here, we report that protein kinase Cdelta (PKCdelta) mediates
LPA induced
NF-kappaB transcription and interleukin-8 (IL-8) secretion in HBEpCs ...
LPA caused a marked activation of NF-kappaB in HBEpCs as determined by IkappaB phosphorylation and of NF-kappaB nuclear translocation and a strong induction of
NF-kappaB promoter
mediated luciferase activity ... Furthermore, LPA activated PKCdelta and the
LPA mediated activation of
NF-kappaB and IL-8 production were attenuated by overexpression of dominant negative PKCdelta and rottlerin
Hwang et al., Mol Carcinog 2006
(Neoplasm Invasiveness...) :
The
LPA induced
NF-kappaB DNA binding was preceded by transient IkappaBalpha phosphorylation, and decreased total IkappaBalpha levels ... The
LPA induced Matrigel invasion and
NF-kappaB DNA binding activity were both inhibited by expression of the RhoA inhibitor C3 exoenzyme or dominant negative mutant NF-kappaB inhibitor IkappaBalpha S32/36A ... Each inhibitor blocked LPA induced invasion while PDTC inhibited
LPA induced
NF-kappaB and invasion to the greatest extent
Sotiriou et al., FASEB J 2006
(Atherosclerosis...) :
Through its interaction with Mac-1,
Lp(a) induced activation of the proinflammatory transcription factor
NFkappaB , as well as the NFkappaB related expression of prothrombotic tissue factor
Klemm et al., Proc Natl Acad Sci U S A 2007
:
Here, we identify the adapter proteins Bcl10 and Malt1 as essential mediators of
LPA induced
NF-kappaB activation ... By using murine embryonic fibroblasts from Bcl10- or Malt1-deficient mice as a genetic model, we report that Bcl10 and Malt1 are critically required for the degradation of IkappaB-alpha and the subsequent
NF-kappaB induction in
response to
LPA stimulation ... Bcl10 and Malt1 cooperate with PKCs selectively for
LPA induced
NF-kappaB activation but are dispensable for the activation of the Jnk, p38, Erk MAP kinase, and Akt signaling pathways
Mahanivong et al., Oncogene 2008
(Neoplasm Invasiveness...) :
Although constitutively active mutants of PKCalpha ( a cPKC ), PKCtheta ( a novel PKC ( nPKC ) ) and PKCzeta ( an atypical PKC ( aPKC ) ) were all able to activate NF-kappaB and upregulate uPA expression, only dominant negative PKCalpha mutant attenuated
LPA induced
NF-kappaB activation and uPA upregulation ... These results suggest that PKCalpha, rather than PKC isoforms in other PKC classes, participates in
LPA induced
NF-kappaB activation and uPA upregulation in ovarian cancer cells
Sebban-Benin et al., Hum Mol Genet 2007
(Incontinentia Pigmenti) :
Mutation of all these ubiquitination sites severely impaired
NF-kappaB activation
induced by stimulation with IL-1, LPS, Nod2/RICK or
serum/LPA
Chen et al., J Cell Biochem 2008
(Hypertrophy...) :
In addition,
LPA stimulated the phosphorylation of Akt and p65 protein and
activated NF-kappaB-luciferase expression ... Furthermore, ERK inhibitors ( U0126 and PD98059 ) suppressed
LPA stimulated activation of
NF-kappaB and p65 phosphorylation whereas wortmannin showed no effect on NF-kappaB activation
Hu et al., Cell Signal 2008
(Burkitt Lymphoma...) :
The increase in VEGF expression by LPA is mediated by the activation of c-Jun N-terminal Kinase (JNK) and transcription factor NFkappaB since blocking JNK or
NFkappaB activation
inhibited LPA induced VEGF expression
Arita et al., World J Gastroenterol 2008
(Adenocarcinoma...) :
To clarify whether
Lysophosphatidic acid (LPA) activates the nuclear translocation of
nuclear factor-kappaB (NF-kappaB) in pancreatic cancer ...
LPA also
caused the nuclear translocation of
NF-kappaB ... Staurosporine, a protein kinase C inhibitor, attenuated translocation of
NF-kappaB induced by
LPA ... These findings suggest that protein kinase C is activated endogenously in Panc-1, and protein kinase C is essential for activating NF-kappaB with cytosolic calcium and that
LPA induces the nuclear translocation of
NF-kappaB in Panc-1 by mobilizing cytosolic free calcium
Medoff et al., Am J Respir Cell Mol Biol 2009
(Asthma) :
We then show that inhibition of CARMA3 activity in airway epithelial cells reduces
LPA mediated
NF-kappaB activity and the production of TSLP and CCL20
Sun et al., Proc Natl Acad Sci U S A 2008
:
Although LPA induced signaling pathways have been intensively investigated, the molecular mechanism by which
LPA activates
NF-kappaB is not fully defined ... In this work, we found that beta-arrestin 2, but not beta-arrestin 1, is required for
LPA induced
NF-kappaB activation and interlukin-6 expression
Kalari et al., Am J Physiol Lung Cell Mol Physiol 2009
(MAP Kinase Signaling System) :
Furthermore, downregulation of native AGK by AGK small interfering RNA decreased intracellular LPA levels ( approximately 2-fold ) and attenuated
LPA induced p38 MAPK, JNK, and
NF-kappaB activation, tyrosine phosphorylation of EGF-R, and IL-8 secretion
N'Diaye et al., Life Sci 2009
(Atherosclerosis) :
DNA binding activity of
NF-kappaB , a well-known molecular effector of TNFalpha, was moreover
activated by
Lp(a) in a TNFalpha dependent manner and the use of the NF-kappaB inhibitor Bay 11-7082 blocked Lp(a) triggered CCL1 induction ... In addition,
Lp(a) induced binding of
NF-kappaB to a NF-kappaB consensus element on CCL1 promoter as assessed by EMSA
Sun et al., Cell Signal 2009
:
Although
LPA induces
NF-kappaB activation by acting on its GPCR receptor, the molecular mechanism of LPA receptor mediated NF-kappaB activation remains to be well defined
Oyesanya et al., Molecular cancer 2010
(Neoplasm Invasiveness) :
In contrast,
LPA stimulated another prominent transcription factor
NF-kappaB via the Gq-PKC pathway in an EGFR independent manner ... In contrast,
activation of G12/13, Gq and Gq-elicited
NF-kappaB by
LPA is independent of such an input
Sun et al., J Biol Chem 2010
:
MEKK3 is a central intermediate signaling component in
lysophosphatidic acid (LPA) induced activation of the
nuclear factor-kappaB (NF-kappaB) ... Furthermore, knockdown of PP2Ac expression enhances
LPA induced MEKK3 mediated IkappaB kinase beta (IKKbeta) phosphorylation and
NF-kappaB activation ... These data suggest that PP2A plays an important role in the termination of
LPA mediated
NF-kappaB activation through dephosphorylating and inactivating MEKK3
Crone et al., Molecular cancer 2012
(Disease Models, Animal...) :
Lysophosphatidic acid (LPA) induces
NF-kappaB activation via this pathway and over-expression of miR-146a
inhibited LPA induced NF-kappaB activation, reduced LPA induced expression of tumor promoting cytokines and growth factors and inhibited monocyte attraction