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BDNF — PLCG1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Goggi et al., Brain Res 2003
:
Three proteins mediating signalling pathways are
activated by the binding of
BDNF to TrkB : phosphoinositol-3 kinase (PI3K) ; Ras-MEK and
phospholipase C-gamma ( PLCgamma )
Pereira et al., J Neurosci Res 2006
:
The small effect of BDNF on [ ( 3 ) H ] glutamate release correlated with a modest
increase in
phospholipase Cgamma ( PLCgamma ) phosphorylation, and with the lack of effect of
BDNF on extracellular-signal regulated kinase ( ERK ) and Akt phosphorylation
Huang et al., Int J Oncol 2010
(Carcinoma, Transitional Cell...) :
The TrkB Ab at 0.5 microg/ml, which did not show cytotoxicity, suppressed migration of TCC cells and invasion of BFTC905 cells, possibly mediated through increased E-cadherin, decreased
BDNF stimulated
phospho-PLCgamma1 and reduced MMP-9 activity
Cortese et al., J Neurosci 2011
(Escherichia coli Infections) :
Aging and a peripheral immune challenge interact to reduce mature
brain derived neurotrophic factor and
activation of TrkB,
PLCgamma1 , and ERK in hippocampal synaptoneurosomes
Nakagawara et al., Mol Cell Biol 1994
(Neuroblastoma) :
Exogenous
BDNF induces tyrosine phosphorylation of TRK-B as well as phosphorylation of
phospholipase C-gamma 1 , the extracellular signal regulated kinases 1 and 2, and phosphatidylinositol-3 kinase
Widmer et al., J Neurochem 1993
:
The present study analyzed the
effects of
brain derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) on phosphorylation of
PLC-gamma 1 in primary cultures of embryonic rat brain cells ...
BDNF and NT-3
stimulated the phosphorylation of
PLC-gamma 1 , followed by hydrolysis of PI
Machide et al., J Neurochem 1998
:
As expected from these three PKC subspecies, phosphorylation of
phospholipase C gamma1 ( PLC gamma1 ) but not phosphatidylinositol 3-kinase was
enhanced , although the stimulation of
brain derived neurotrophic factor induced phosphorylation of phosphatidylinositol 3-kinase