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IGF2 — LEPR

Text-mined interactions from Literome

Garofalo et al., Clin Cancer Res 2006 (Breast Neoplasms...) : The effects of insulin, IGF-I , estradiol, and hypoxia on leptin and ObR mRNA expression were assessed by reverse transcription-PCR in MCF-7 and MDA-MB-231 breast cancer cell lines
Saxena et al., Cancer Res 2008 (Breast Neoplasms...) : We found a novel bidirectional crosstalk between leptin and IGF-I signaling ; IGF-I induced phosphorylation of leptin receptor ( Ob-Rb ) and leptin induced phosphorylation of IGF-I receptor (IGF-IR), whereas cotreatment induced synergistic phosphorylation and association of Ob-Rb and IGF-IR along with activation of downstream effectors, Akt and extracellular signal regulated kinase