Cui et al., Mol Cell Endocrinol 2007
:
Experimental results suggest that WISP3 up-regulates collagen II expression and inhibits the activation of IGF-IR , IRS-1, and ERK kinase in human chondrocytes, and mutation of WISP3 augments IGF signaling in human chondrocytes
Repudi et al., J Cell Sci 2013
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Interestingly, both IGF1 and ROS in turn trigger an increase in WISP3 expression