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ALOX5 — GPX1

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• MIPS Negatome - no physical interaction between proteins Interaction: GPX1 — ALOX5 (Absence of interaction, affinity chromatography technologies) Straif et al., Biochem J 2000*

Text-mined interactions from Literome

Straif et al., Biochem J 2000 : Glutathione peroxidase-1 but not -4 is involved in the regulation of cellular 5-lipoxygenase activity in monocytic cells
Hatzelmann et al., Eur J Biochem 1989 : Involvement of glutathione peroxidase activity in the stimulation of 5-lipoxygenase activity by glutathione depleting agents in human polymorphonuclear leukocytes ... At higher arachidonate concentrations and in the presence of Ca2+ the glutathione effect was not observed but additional glutathione peroxidase also blocked this maximally stimulated 5-lipoxygenase
Werz et al., Mol Pharmacol 1998 : Nonredox 5-lipoxygenase inhibitors require glutathione peroxidase for efficient inhibition of 5-lipoxygenase activity