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CTNNB1 — SMAD4

Pathways - manually collected, often from reviews:

• BioCarta wnt signaling pathway: beta-catenin/TCF/CtBP1/CBP/TLE1/SMAD4 complex (CTNNB1-TCF1-CTBP1-CREBBP-TLE1-SMAD4) → CtBP1/CBP/TCF/TLE1 complex (CTBP1-CREBBP-TCF1-TLE1) (transcription, activates)
  
• BioCarta wnt signaling pathway: beta-catenin (CTNNB1) → beta-catenin/TCF/CtBP1/CBP/TLE1/SMAD4 complex (CTNNB1-TCF1-CTBP1-CREBBP-TLE1-SMAD4) (modification, collaborate)
  
• BioCarta wnt signaling pathway: NLK → beta-catenin/TCF/CtBP1/CBP/TLE1/SMAD4 complex (CTNNB1-TCF1-CTBP1-CREBBP-TLE1-SMAD4) (modification, inhibits)
  
• BioCarta wnt signaling pathway: beta-catenin/TCF/CtBP1/CBP/TLE1/SMAD4 complex (CTNNB1-TCF1-CTBP1-CREBBP-TLE1-SMAD4) → CtBP1/CBP/TCF/TLE1 complex (CTBP1-CREBBP-TCF1-TLE1) (modification, collaborate)
  
• BioCarta wnt signaling pathway: beta-catenin/TCF/CtBP1/CBP/TLE1/SMAD4 complex (CTNNB1-TCF1-CTBP1-CREBBP-TLE1-SMAD4) → CtBP1/CBP/TCF/TLE1 complex (CTBP1-CREBBP-TCF1-TLE1) (transcription, activates)
  
• BioCarta wnt signaling pathway: beta-catenin/TCF/CtBP1/CBP/TLE1/SMAD4 complex (CTNNB1-TCF1-CTBP1-CREBBP-TLE1-SMAD4) → PPAR-delta (PPARD) (transcription, activates)
• BioCarta wnt signaling pathway: beta-catenin/TCF/CtBP1/CBP/TLE1/SMAD4 complex (CTNNB1-TCF1-CTBP1-CREBBP-TLE1-SMAD4) → CtBP1/CBP/TCF/TLE1 complex (CTBP1-CREBBP-TCF1-TLE1) (transcription, activates)
  
• BioCarta wnt signaling pathway: beta-catenin/TCF/CtBP1/CBP/TLE1/SMAD4 complex (CTNNB1-TCF1-CTBP1-CREBBP-TLE1-SMAD4) → CYCLIN D1 (CCND1) (transcription, activates)
• WikiPathways Endoderm Differentiation: SMAD4 → CTNNB1 (unknown)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: CTNNB1 — SMAD4 (physical association, affinity chromatography technology) Tian et al., Am J Pathol 2002*
• IRef Hprd Interaction: CTNNB1 — SMAD4 (in vivo) Tian et al., Am J Pathol 2002*
• IRef Ophid Interaction: CTNNB1 — SMAD4 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Li et al., Development 2003 (Abscess...) : We demonstrated that absence of Smad4 resulted in beta-catenin accumulation at onset and throughout the process of transdifferentiation, implicating beta-catenin, a key component of the Wnt signaling pathway, in the development of squamous metaplasia in Smad4-null mammary glands
Chakladar et al., Biochem Biophys Res Commun 2005 : Synergistic activation of the murine gastrin promoter by oncogenic Ras and beta-catenin involves SMAD recruitment
Han et al., Dev Cell 2006 : Further analysis revealed that independent of its role in anti-Smad signaling, Smad7 bound beta-catenin and induced beta-catenin degradation by recruiting an E3 ligase, Smurf2, to the Smad7/beta-catenin complex
Hirota et al., Cell Signal 2008 : Indeed, the enhancement of beta-catenin/Tcf4 transcriptional activity by activated Smad2 was negatively regulated by the presence of Smad4
Yang et al., Bone 2009 : Both activated or total nuclear Smad158 and Smad2 levels increase as they become confluent, and beta-catenin protein expression increases as 2T3 cells become confluent, reflecting a set of genes involved in early preosteoblast to osteoblast commitment, as observed in vitro and in vivo
Zhang et al., J Biol Chem 2010 : Both Smad3 and Smad4 were required for the interaction with beta-catenin and protected beta-catenin from an ubiquitin-proteasome dependent degradation
Hirata et al., PloS one 2012 (Urinary Bladder Neoplasms) : MiR-182-5p also increased nuclear beta-catenin expression and while Smad4 repressed nuclear beta-catenin expression