Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
THRA
→
BRD8
(increases, BRD8 Activity)
Monden et al., J Biol Chem 1997* Evidence: Interaction studies demonstrate that p120 interacts with the TR AF-2 domain in the presence of ligand through a 111-amino acid region. Northern analysis demonstrates widespread expression in human tissues. Cotransfection assays in CV-1 cells demonstrate that p120 enhances TR-mediated transactivation on multiple T3 response elements in the presence of T3. In addition, CREB-binding protein synergizes with p120 to enhance this effect.