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KLF5 — KRAS

Text-mined interactions from Literome

Nandan et al., Gastroenterology 2008 (Cell Transformation, Neoplastic...) : Induction of KRAS ( V12G ) in IEC-6 cells resulted in increased expression of KLF5 , accompanied by increased rates of proliferation and anchorage independent growth
Mori et al., Mol Cancer Res 2009 (Pancreatic Neoplasms) : Surprisingly, inhibition of B-Raf/C-Raf or MAPK/Erk did not reduce KLF5 levels, suggesting that KLF5 expression is not promoted by KRAS-Raf-MEK-Erk signaling in pancreatic cancer ... In conclusion, overexpression of KLF5 in human pancreatic cancer cells is not mediated by KRAS/Raf/MAPK/Erk signaling, but involves the IL-1beta/IL-1R system, p38, and the transcription factor HIF-1alpha