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CBX8 — CCND1

Text-mined interactions from Literome

Guardavaccaro et al., Mol Cell Biol 2000 : Furthermore, ( i ) the arrest of G ( 1 ) -S transition exerted by PC3 was completely rescued by coexpression of cyclin D1 but not by that of cyclin A or E ; ( ii ) expression of PC3 caused a significant down-regulation of cyclin D1 protein levels, also in Rb-defective cells, accompanied by inhibition of CDK4 activity in vivo ; and ( iii ) the removal from the PC3 molecule of residues 50 to 68, a conserved domain of the PC3/BTG/Tob gene family, which we term GR, led to a loss of the inhibition of proliferation as well as of the down-regulation of cyclin D1 levels
Farioli-Vecchioli et al., FASEB J 2007 (Basal Cell Nevus Syndrome...) : The PC3 mediated inhibition of cyclin D1 expression correlates with recruitment of PC3 to the cyclin D1 promoter, which is accompanied by histone deacetylation
Evangelisti et al., Cell Signal 2009 : Using DNA microarrays, Real-Time RT-PCR and western blot, we demonstrated that nuclear DGK-zeta downregulated the expression of cyclin D1 and increased the expression of TIS21/BTG2/PC3 , a transcriptional regulator of cyclin D1 with a strong anti-proliferative function