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CCND1 — STAT5A
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Matsumura et al., EMBO J 1999
:
Transcriptional
regulation of the
cyclin D1 promoter by
STAT5 : its involvement in cytokine dependent growth of hematopoietic cells ... In NIH 3T3 cells,
1*6-STAT5A and H-rasG12V individually and cooperatively
transactivated the
cyclin D1 promoter in luciferase assays ... Both
dn-STAT5 and dn-ras
suppressed IL-3 induced
cyclin D1 promoter activities in F-36P-mpl cells
Magné et al., Mol Cell Biol 2003
:
Among the target genes involved in cell growth,
STAT5 had been shown to
activate cyclin D1 gene expression
Dagvadorj et al., Clin Cancer Res 2008
(Prostatic Neoplasms) :
The
effects of
Stat5a/b on the viability of prostate cancer cells involve Stat5a/b regulation of Bcl-X ( L ) and
cyclin D1 protein levels but not the expression or activation of Stat3
José-Enériz et al., Br J Haematol 2008
(Leukemia, Myelogenous, Chronic, BCR-ABL Positive) :
In conclusion, our studies suggest that
STAT5 mediated activation of HSPA8
induces nuclear translocation and activation of the
CCND1/CDK4 complex leading to increased proliferation of CML cells, deciphering a new pathway implicated in CML and supporting a potential role of chaperone inhibitors in the treatment of CML
Guo et al., Biochem Pharmacol 2009
:
Involvement of
STAT5a signaling in morphine induced up-regulation of the
cyclin D1
Kalita et al., IUBMB Life 2013
:
Overexpression studies confirmed increase in
cyclin D1 expression in
response to
STAT5a and STAT5b constructs when compared to dominant negative STAT5 ... siRNA targeting STAT5, diminished the cyclin D1 expression, further confirming that
STAT5 specifically
regulated cyclin D1 in neuronal cells