◀ Back to PIK3R1

PIK3R1 — PTGES

Text-mined interactions from Literome

Black et al., Toxicol Appl Pharmacol 2008 : While inhibition of PI3K suppressed UVB induced mPGES-1 and CRTH2 expression, JNK inhibition suppressed mPGES-1, PGIS, EP2 and CRTH2, and p38 kinase inhibition only suppressed EP1 and EP2
de Oliveira et al., Journal of neuroinflammation 2012 : Interestingly, NVP-BEZ235, a dual PI3K/mTOR inhibitor, enhanced COX-2 and reduced mPGES-1 immunoreactivity, albeit PGE2 and PGD2 levels were enhanced in LPS stimulated microglia ... Taken together, we demonstrate that blockade of mTOR and/or PI3K/Akt enhances prostanoid production and that PI3K/Akt , GSK-3 and mTOR differently regulate the expression of mPGES-1 and COX-2 in activated primary microglia