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IL3 — KITLG
Text-mined interactions from Literome
Kawasaki et al., Int J Hematol 2002
(Anemia, Diamond-Blackfan) :
We conclude that TPO enhances bone marrow erythropoiesis in patients with DBA in the
presence of EPO and
SCF and/or
IL-3
Okada et al., Blood 1992
:
Lin-c-kit+Sca-1+ cells formed no colonies in the
presence of
stem cell factor (SCF) or interleukin-6 (IL-6), and only 10 % of them formed colonies in the presence of
IL-3
Goselink et al., Blood 1992
(Acute Disease...) :
In contrast, in the
presence of
IL-3 and/or GM-CSF,
MGF strongly induced both size and number of leukemic colonies from patients with CML in chronic phase ... In the absence of exogenous EPO and in the presence of 10 % human AB serum,
MGF in the
presence of
IL-3 and/or GM-CSF induced erythroid colony formation from normal bone marrow and patients with MDS or CML, illustrating that MGF greatly diminished the EPO requirement for erythroid differentiation
Kitayama et al., Int J Oncol 1993
:
When purified c-kit positive cells ( approximately 20 % of KU812F cells ) were used as a target,
SCF induced not only proliferation but also augumented erythroid differentiation of the cells, while
IL-3 did promote basophilic differentiation
Walsh et al., J Investig Med 1995
(Fanconi Anemia) :
For FA ( C ) hematopoietic cell infection, vector supernatant transduction in the
presence of recombinant human
IL-3 , IL-6, and
SCF was found to be superior to transduction supported by autologous FA ( C ) patient stroma
Erickson-Miller et al., Stem Cells 1993
:
On the other hand,
SCF increased the number of megakaryocytes per colony in the presence of
IL-3 , GM-CSF or IL-6
Rottem et al., J Immunol 1993
:
Analysis of this data revealed that
SCF in the
presence of
IL-3 promoted the development of mast cells, although a significant number of basophils were noted at day 21 but were absent by day 42 ... Thus,
SCF in the
presence of
IL-3 increases the ratio of mast cells to basophils and alters the ultrastructural characteristics of mast cells and basophils toward a more mature phenotype