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CASP3 — RIPK2
Text-mined interactions from Literome
Lee et al., J Biol Chem 2001
:
COP binds to both RIP2 and the caspase-1 prodomain and inhibits
RIP2 induced
caspase-1 oligomerization
Sarkar et al., J Immunol 2006
:
This
RIP2 induced NF-kappaB activity and
caspase-1 binding was inhibited in a dose dependent fashion by ASC
da Silva Correia et al., Cell Death Differ 2007
(Breast Neoplasms) :
In contrast, several lines of evidence show that Nod1 dependent JNK activation and IL-8 production did not require the presence of
caspase 8 but
required activation of TAK1 as well as
RIP2
Gentle et al., J Biol Chem 2011
:
After receptor ligation,
RIPK1 not only modulates activation of both canonical and NIK dependent NF-?B, but also
regulates caspase-8 activation and cell death
Oh et al., J Pharmacol Exp Ther 2011
(Inflammation...) :
In activated human mast cells, the
receptor interacting protein 2 (RIP2) , I?B kinase ( IKK ) -ß, nuclear factor-?B ( NF-?B ) /RelA, and caspase-1 activation were increased, but increased RIP2, IKK-ß, NF-?B/RelA, and
caspase-1 activation were
inhibited by the treatment of IPT
Duprez et al., Immunity 2011
(Cecal Diseases...) :
An additional switch decides, depending on the cellular context, between
caspase dependent apoptosis and
RIP kinase ( RIPK ) -mediated necrosis, also termed necroptosis