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CA2 — NFKB1

Text-mined interactions from Literome

Hsuan et al., Microb Pathog 1999 : The role of Ca2+ and tyrosine kinases in NF-kappaB activation and inflammatory cytokine gene expression was studied, since an inhibitor of tyrosine kinases attenuates LPS induced [Ca2+ ] i elevation in BAMs
Tando et al., Am J Physiol 1999 (Second Messenger Systems) : Caerulein induced NF-kappaB/Rel activation requires both Ca2+ and protein kinase C as messengers ... Here, we show that activation of NF-kappaB/Rel by caerulein, a CCK analog, requires increasing intracellular Ca2+ levels and protein kinase C activation
Quinlan et al., J Immunol 1999 (Calcium Signaling) : The SP-elicited intracellular Ca2+ signal was required for activation and subsequent binding of both NF-AT and NF-kappa B
Takuma et al., Eur J Neurosci 1999 (Reperfusion Injury) : These findings indicate that Ca2 + reperfusion induced apoptosis is mediated at least partly by ROS production and ROS cause NF-kappaB activation in cultured astrocytes
Morigiwa et al., Nihon Yakurigaku Zasshi 2000 : Release of cytokines may be induced via Ca2+ influx and activation of NFAT, NF-kappa B or p44/42 and p38 MAP kinases, switching off the mitotic signal transduction pathway and triggering the apoptotic cascade at the same time
Aifantis et al., Nat Immunol 2001 (Calcium Signaling) : Constitutive pre-TCR signaling promotes differentiation through Ca2+ mobilization and activation of NF-kappaB and NFAT
El Bekay et al., Blood 2003 (Calcium Signaling...) : Ang II increased cytosolic Ca2+ levels released mainly from calcium stores enhanced the synthesis de novo and activity of calcineurin, and stimulated the DNA binding activity of the transcription factor NF-kappaB in cultured human neutrophils
Miyakawa-Naito et al., J Biol Chem 2003 : Partial truncation of the NH2 terminus of Na, K-ATPase catalytic alpha1-subunit abolished Ca2+ oscillations and downstream activation of NF-kappaB
Lin et al., J Biol Chem 2004 (Inflammation...) : Cr3 induces inflammatory cytokine secretion by activating NF-kappaB and p38 mitogen activated protein kinase in a Ca2+ dependent manner, but influx by extra-cellular Ca2+ is not involved
Mitsuyama et al., J Bone Miner Res 2004 (Calcium Signaling) : These results show that the Ca2+ signaling pathway involving calcineurin regulates IL-8 gene expression through activation of NF-kappaB in human osteoblast-like cells
Venkatesha et al., J Biol Chem 2004 : Furthermore, a Ca2+/calcineurin inhibitor completely inhibited PAF induced NFAT activation and CCL2 production but not NF-kappaB activation
Zhi et al., J Cell Physiol 2006 (Inflammation) : Moreover, our data shows that SPHK1 is the isoform activated by TNFalpha, and plays an essential role on the TNFalpha triggered intracellular Ca2+ signals, degranulation, cytokine production, and activation of NFkappaB , thus suggesting a pivotal role for SPHK1 on the proinflammatory responses triggered by TNFalpha
Zhou et al., J Biol Chem 2006 : Therefore, these results revealed the following roles of Ca2+ and PKC in the signaling pathway for NF-kappaB activation in LPS stimulated macrophages
Bair et al., J Biol Chem 2009 (Thrombosis) : Ca2+ signaling is involved in NF-kappaB activation, but the role of store operated Ca2+ entry is unclear
Kang et al., Pharmacol Res 2009 : Resveratrol suppressed the expression of TNF-alpha, IL-6, IL-8 and COX-2 through a decrease in the intracellular levels of Ca2+ and ERK 1/2, as well as activation of NF-kappaB
Jeon et al., Cell Mol Life Sci 2010 : Annexin A4 interacts with the NF-kappaB p50 subunit and modulates NF-kappaB transcriptional activity in a Ca2+ dependent manner
Jenkins et al., J Immunol 1995 (Leukemia-Lymphoma, Adult T-Cell) : We show in this work that mutations in either the purine-rich region of the CLEO element or the NF-kappa B site result in reduced PMA/Ca2+ activation of a 620-bp human GM-CSF promoter-luciferase reporter construct in Jurkat T cells by 65 % and 50 %, respectively
Sen et al., FEBS Lett 1996 : Involvement of intracellular Ca2+ in oxidant induced NF-kappa B activation ... In Jurkat cells that are not sensitive to H2O2 induced NF-kappaB activation, H2O2 potentiated NF-kappaB activation in the presence of sustained high [Ca2+ ] i following thapsigargin treatment
Marinovich et al., Exp Cell Res 1996 : These findings suggest that TPT increases intracellular Ca2+ , alters actin polymerization and the cytoskeleton, and induces NF-kappaB activation, TNF-alpha synthesis, DNA degradation, and apoptosis
Pahl et al., FEBS Lett 1996 : Activation of NF-kappa B by ER stress requires both Ca2+ and reactive oxygen intermediates as messengers ... Consistent with an involvement of calcium, the ER-resident Ca2+-ATPase inhibitors thapsigargin and cyclopiazonic acid (CPA), which trigger a rapid efflux of Ca2+ from the ER, also potently activated NF-kappaB
Pahl et al., Trends Biochem Sci 1997 : Both the release of Ca2+ from the ER and the subsequent production of reactive oxygen intermediates are required for ER-overload mediated NF-kappa B activation
Ko et al., J Neurochem 1998 : NMDA treatment also enhanced the DNA binding activity of nuclear NF-kappaB in a Ca2+ dependent manner