Gene interactions and pathways from curated databases and text-mining

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NFKB1 — TNFRSF1A

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Pimentel-Muiños et al., Immunity 1999 : We show that in T cells, TNFR2 ( TNFRSF1B ) signaling is dramatically affected by the intracellular mediator RIP, a protein Ser/Thr kinase required for NF-kappaB activation by TNFR1 ( TNFRSF1A )
Burow et al., Biochem Biophys Res Commun 2000 : We demonstrate that while both TNFR1 and NIK are partially involved in Akt induced NF-kappaB stimulation, a dominant negative IkappaBalpha completely blocked Akt-NF-kappaB cross-talk
Gaeta et al., Lab Invest 2000 : Overexpressed TNFR1 ( -DD ) did not activate NF-kappaB but acted as a ligand-specific dominant negative inhibitor of TNF actions
Manna et al., J Immunol 2000 : We in this study show that leflunomide also blocks NF-kappaB reporter gene expression induced by TNFR1 , TNFR associated factor 2, and NF-kappaB inducing kinase (NIK), but not that activated by the p65 subunit of NF-kappaB, suggesting that leflunomide acts downstream of NIK
Wajant et al., Int J Biochem Cell Biol 2001 : TRAF 2 is currently the best characterized TRAF family member, having a key role in mediating TNF-R1 induced activation of NF-kappaB and JNK
Matsushima et al., J Exp Med 2001 : Essential role of nuclear factor (NF)-kappaB inducing kinase and inhibitor of kappaB (IkappaB) kinase alpha in NF-kappaB activation through lymphotoxin beta receptor, but not through tumor necrosis factor receptor I
Fotin-Mleczek et al., J Cell Sci 2002 (Rhabdomyosarcoma) : When both TNF-receptors were stimulated simultaneously, TNF-R1 induced NF-kappaB activation remained unaffected but TNF-R1 induced apoptosis was still significantly enhanced
Sun et al., J Biol Chem 2003 : TNF-R1 activates both caspase mediated apoptosis and NF-kappaB transcription of anti-apoptotic factors
Fotin-Mleczek et al., J Biol Chem 2004 : Accordingly, TRAF1 inhibited CD40 dependent but not TNF-R1 dependent NF-kappaB activation
Soond et al., Mol Cell Biol 2003 : Transient overexpression of TRUSS activated NF-kappaB and increased NF-kappaB activation in response to ligation of TNF-R1
Marchetti et al., J Biol Chem 2004 : Both TNFR1 and TNFR2 induced the NF-kappa B pathway, yet with distinguishable kinetics and upstream activating components, TNFR1 only induced transient NF-kappa B activation, whereas TNFR2 facilitated long term phosphatidylinositol 3-kinase dependent NF-kappa B activation strictly
Doan et al., J Immunol 2004 : Differential regulation of TNF-R1 signaling : lipid raft dependency of p42mapk/erk2 activation, but not NF-kappaB activation
Pradillo et al., J Cereb Blood Flow Metab 2005 (Brain Ischemia) : In summary, these data show that IPC produces neuronal upregulation of TACE and TNFR1 , and that the pathway TACE/TNF-alpha/TNFR1/NF-kappaB is involved in IT
Yousaf et al., Arthritis Rheum 2005 (Familial Mediterranean Fever) : Tumor necrosis factor receptor I from patients with tumor necrosis factor receptor associated periodic syndrome interacts with wild-type tumor necrosis factor receptor I and induces ligand independent NF-kappaB activation
Aggarwal et al., Mol Pharmacol 2006 (Neoplasm Metastasis) : Curcumin also suppressed NF-kappaB reporter activity induced by tumor necrosis factor receptor (TNFR)1 , TNFR2, NF-kappaB inducing kinase, IkappaB kinase complex (IKK), and the p65 subunit of NF-kappaB
Shishodia et al., Cancer Res 2005 (Carcinoma, Small Cell...) : NF-kappaB dependent reporter gene expression was also suppressed by 4-HPR, as was NF-kappaB reporter activity induced by TNFR1 , TRADD, TRAF2, NIK, and IKK but not that induced by p65 transfection
Su et al., Exp Cell Res 2006 (MAP Kinase Signaling System) : Although both DR3 and TNFRI activated TRAF2 and NF-kappaB to induce IL-8 gene transcription, the kinase cascades that transduce signals for DR3- and TNFRI induced IL-8 gene transcription are different
Sethi et al., J Biol Chem 2006 : NF-kappaB reporter activity induced by TNFR1 , TNF receptor associated death domain, TRAF2, TAK1, NF-kappaB inducing kinase, and IKKbeta was inhibited by indirubin but not that induced by p65 transfection
Hunter et al., J Biol Chem 2006 : TNF-alpha engagement of TNFR1 recruited the adaptor proteins TRADD, TRAF-2, and RIP into lipid rafts and activated RhoA, NF-kappaB , and MAPK pathways
Nair et al., J Immunol 2006 (Neoplasm Invasiveness) : Deguelin also suppressed the NF-kappaB reporter activity induced by TNFR1 , TNFR associated death domain, TNFR associated factor 2, and IkappaBalpha kinase, but not that induced by p65
Kilpatrick et al., J Leukoc Biol 2006 (MAP Kinase Signaling System) : delta-PKC associates with TNFR-1 in response to TNF and is required for NFkappaB activation and inhibition of caspase 3
Sung et al., Mol Pharmacol 2007 : NF-kappaB dependent reporter gene expression was also suppressed by fisetin, as was NF-kappaB reporter activity induced by TNFR1 , TRADD, TRAF2, NIK, and IKK but not that induced by p65 transfection
Wosik et al., J Neurol Sci 2007 : TNFR1 ligation induces NFkappaB activation and the upregulation of chemokines MCP-1 and IL-8, as well as adhesion molecules ICAM-1 and VCAM-1, while Fas and DR5 triggering activate the extracellular signal regulated kinases-1 and -2 ( Erk 1/2, p42/44 MAPK ) inducing the release of matrix metalloproteinase 9 (MMP9) by BBB derived ECs
Pandey et al., J Biol Chem 2007 : As examined by DNA binding, we found that butein suppressed tumor necrosis factor (TNF) induced NF-kappaB activation in a dose- and time dependent manner ; suppressed the NF-kappaB activation induced by various inflammatory agents and carcinogens ; and inhibited the NF-kappaB reporter activity induced by TNFR1 , TRADD, TRAF2, NIK, TAK1/TAB1, and IKK-beta
Sethi et al., J Immunol 2007 : NF-kappaB reporter assay revealed that NF-kappaB activation induced by TNF, TNFR1 , TRADD, TRAF2, NIK, and I kappaB alpha kinase was modulated in gene deleted cells
Schneider et al., PLoS Biol 2008 : The tumor necrosis factor (TNF)-receptor 1-associated death domain protein ( TRADD ) mediates induction of apoptosis as well as activation of NF-kappaB by cellular TNF-receptor 1 (TNFR1)
Sethi et al., Mol Cancer Ther 2008 (Neoplasm Invasiveness...) : Pinitol also suppressed the NF-kappaB reporter activity induced by tumor necrosis factor receptor (TNFR)-1 , TNFR associated death domain, TNFR associated factor-2, transforming growth factor-beta activated kinase-1 ( TAK-1 ) /TAK1 binding protein-1, and IkappaBalpha kinase but not that induced by p65
Sethi et al., Biochem Pharmacol 2008 (Neoplasm Invasiveness) : This led to suppression of the phosphorylation and translocation of p65 and also of NF-kappaB reporter activity induced by TNFR1 , TRADD, TRAF2, NIK, and IKKbeta but not that induced by p65 transfection
Pincheira et al., J Immunol 2008 : TNFR1/c-Src, but not TNFR1/Jak2 , plays an obligate role in the activation of NF-kappaB by TNF, whereas TNFR1/Jak2, but not TNFR1/c-Src, plays an obligate role in the activation of STAT3
Itatsu et al., Liver Int 2009 (Cholangiocarcinoma) : These data suggest that TNF-alpha/TNF-R1 interaction leads to the phosphorylation of Erk1/2 and p38MAPK and nuclear translocation of NF-kappaB , which is closely associated with the production and activation of MMP-9 in cultured CC cells of HuCTT-1 and CCKS-1
Kieser et al., Biol Chem 2008 : TRADD mediates TNFR1 activation of NF-kappaB and c-Jun N-terminal kinase (JNK), as well as caspase dependent apoptosis
Wicovsky et al., Oncogene 2009 : It has been shown that tumor necrosis factor receptor-2 (TNFR2) stimulation leads to degradation of TNF receptor associated factor-2 (TRAF2) and inhibition of TNFR1 induced activation of NFkappaB and JNK ... Here, we show that TRAF1 inhibits TNFR2 induced proteasomal degradation of TRAF2 and relieves TNFR1 induced activation of NFkappaB from the inhibitory effect of TNFR2 ... Despite lacking an amino-terminal RING/zinc-finger domain, TRAF1 did not interfere with TNFR1 induced activation of JNK and NFkappaB
Fujita et al., Results Probl Cell Differ 2009 (Inflammation...) : Ubiquitin protein ligases ( E3s ), DUBs, and signaling molecules with ubiquitin recognition motifs control TNFR1 mediated cell death and activation of NF-kappaB and JNK
Wong et al., Cell Death Differ 2010 : RIPK1 is not essential for TNFR1 induced activation of NF-kappaB
Kim et al., J Mol Biol 2010 (Fatty Liver) : Our results suggest that HBx induced NF-kappaB activation was mediated by direct interaction with TNFR1 and thereby induced TNF-alpha production
D'Alessio et al., J Biol Chem 2010 : Both knockdowns reduce total TNFR1 protein expression, but neither prevents TNFR1 localization to low density membrane domains, TNF induced internalization of TNFR1 , or NF-kappaB activation by TNF
Al-Lamki et al., Am J Pathol 2010 (Carcinoma, Renal Cell) : TNFR1 , expressed in normal kidney primarily on endothelial cells, activates apoptotic signaling kinase 1 and nuclear factor-kappaB (NF-kappaB) and induces cell death, whereas TNFR2, inducibly expressed on endothelial cells and on TECs by injury, activates endothelial/epithelial tyrosine kinase (Etk), which trans-activates vascular endothelial growth factor receptor 2 ( VEGFR2 ) to promote cell proliferation
Ting et al., EMBO J 1996 : RIP mediates tumor necrosis factor receptor 1 activation of NF-kappaB but not Fas/APO-1 initiated apoptosis
Sylla et al., Proc Natl Acad Sci U S A 1998 : TNFRI has been recently shown to activate NF-kappaB through association with TRADD, RIP, and TRAF2 ; activation of the NF-kappaB inducing kinase (NIK) ; activation of the IkappaB alpha kinases ( IKKalpha and IKKbeta ) ; and phosphorylation of IkappaB alpha
Yamada et al., Hepatology 1998 : We conclude that TNFR-1 , but not TNFR-2, is necessary for liver regeneration, and that NF-kappaB and STAT3 binding are activated by signals transduced by TNFR-1