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IKBKE — TANK

Pathways - manually collected, often from reviews:

• Reactome Reaction: IKBKE → TANK (reaction) Pomerantz et al., EMBO J 1999, Chariot et al., J Biol Chem 2002, Fitzgerald et al., Nat Immunol 2003, Mori et al., J Biol Chem 2004, Hemmi et al., J Exp Med 2004, Paz et al., Cell Mol Biol Incl Cyto Enzymol 2006, Häcker et al., Science's STKE : signal transduction knowledge environment 2006, Panne et al., J Biol Chem 2007, Konno et al., PloS one 2009, Larabi et al., Cell reports 2013
• Reactome Reaction: IKBKE → TANK (indirect_complex) Pomerantz et al., EMBO J 1999, Chariot et al., J Biol Chem 2002, Fitzgerald et al., Nat Immunol 2003, Hemmi et al., J Exp Med 2004, Häcker et al., Science's STKE : signal transduction knowledge environment 2006, Konno et al., PloS one 2009, Larabi et al., Cell reports 2013
• WikiPathways RIG-I-like Receptor Signaling: Complex of TANK-AZI2-TBKBP1 → IKBKE/TBK1/IKBKG (unknown)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: TANK — IKBKE Chariot et al., J Biol Chem 2002
• IRef Bind_translation Interaction: TANK — IKBKE (coimmunoprecipitation) Chariot et al., J Biol Chem 2002
• IRef Biogrid Interaction: IKBKE — TANK (physical association, affinity chromatography technology) Shen et al., Mol Cell Biol 2012
• IRef Biogrid Interaction: IKBKE — TANK (physical association, affinity chromatography technology) Gatot et al., J Biol Chem 2007
• IRef Biogrid Interaction: IKBKE — TANK (physical association, affinity chromatography technology) Nomura et al., Genes Cells 2000*
• IRef Biogrid Interaction: IKBKE — TANK (direct interaction, two hybrid) Nomura et al., Genes Cells 2000*
• IRef Biogrid Interaction: IKBKE — TANK (physical association, affinity chromatography technology) Ryzhakov et al., EMBO J 2007
• IRef Biogrid Interaction: IKBKE — TANK (physical association, affinity chromatography technology) Renner et al., EMBO Rep 2011
• IRef Hprd Interaction: IKBKE — TANK (two hybrid) Nomura et al., Genes Cells 2000*
• IRef Hprd Interaction: IKBKE — TANK (in vivo) Nomura et al., Genes Cells 2000*
• IRef Intact Interaction: Complex of 22 proteins (association, anti tag coimmunoprecipitation) Li et al., Immunity 2011
• IRef Intact Interaction: Complex of IKBKE-UBE2I-TANK-SUMO1 (association, pull down) Renner et al., EMBO Rep 2011
• IRef Intact Interaction: Complex of SUMO1-TANK-IKBKE-SUMO1-TANK-IKBKE-TANK-IKBKE-SUMO1 (association, pull down) Renner et al., EMBO Rep 2011
• IRef Intact Interaction: TANK — IKBKE (physical association, anti tag coimmunoprecipitation) Ryzhakov et al., EMBO J 2007
• IRef Intact Interaction: TANK — IKBKE (covalent binding, cross-linking study) Renner et al., EMBO Rep 2011
• IRef Ophid Interaction: TANK — IKBKE (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Nomura et al., Genes Cells 2000 : NF-kappaB activation through IKK-i dependent I-TRAF/TANK phosphorylation ... NF-kappaB activation by IKK-i is significantly blocked by coexpression of the N-terminal domain of I-TRAF , dominant negative TRAF2, and dominant negative NIK and IKK-beta
Gatot et al., J Biol Chem 2007 : Lipopolysaccharide mediated interferon regulatory factor activation involves TBK1-IKKepsilon dependent Lys ( 63 ) -linked polyubiquitination and phosphorylation of TANK/I-TRAF