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CA1 — PTH
Text-mined interactions from Literome
Garg et al., Pflugers Arch 1976
:
Failure of
parathyroid hormone and cyclic AMP to
inhibit renal
carbonic anhydrase
Babich et al., Endocrinology 1991
(Osteosarcoma) :
The additive
effects of
PTH and thrombin on
Cai2+ were confirmed at the single cell level, using laser based image analysis
Dawborn et al., Br J Pharmacol 1977
:
The hypothesis that acetazolamide and
parathyroid hormone (PTH) ,
inhibit renal
carbonic anhydrase by a cyclic adenosine 3',5'-monophosphate ( cyclic AMP ) -dependent mechanism was also tested.2In vitro, acetazolamide, frusemide and ethacrynic acid at high concentrations ( 10 ( -3 ) M ) all produced some inhibition of basal and stimulated rat kidney plasma membrane adenylate cyclase
McHenry et al., Surgery 1990
(Hyperparathyroidism) :
After surgery, three patients had elevated parathormone and low normal
Cai levels and
parathormone response to a CLT confirmed the diagnosis of secondary hyperparathyroidism
Grant et al., J Clin Endocrinol Metab 1990
:
The rapid decline in
CaI resulted in a more marked increase in levels of
PTH , which subsequently fell to levels similar to those with the slower infusion
Burnatowska-Hledin et al., Am J Physiol 1987
:
In MDCK cells, BK, but not AVP and
PTH ,
increased [
Ca]i from 146 +/- 11 to 281 +/- 31 nM ( n = 9, P less than 0.001 )
Hunter et al., J Bone Miner Res 1988
:
The transient increase in acidity may be due to
activation of
carbonic anhydrase by
PTH
Nygren et al., Biosci Rep 1986
:
A deteriorated
Cai2+ regulation and a decreased inhibitory
action of cytoplasmic Ca2+ on
PTH release were also found in cells from human parathyroid adenomas
Arlot-Bonnemains et al., Proc Natl Acad Sci U S A 1985
:
The
effect of calcitonin ( CT ) and
parathyroid hormone (PTH) on
carbonic anhydrase ( carbonate hydrolyase, EC 4.2.1.1. ) activity was tested in human erythrocyte hemolysates and with purified carbonic anhydrases I and II
Anderson et al., Calcif Tissue Int 1985
:
Stimulation of
carbonic anhydrase in osteoclasts by
parathyroid hormone ... Because increased fluorescence of acridine orange is a sign of greater acidity, these results suggest that ( 1 )
PTH stimulates the acidity of osteoclasts, ( 2 ) carbonic anhydrase activity is necessary for maximum acidity, and ( 3 )
carbonic anhydrase is
activated by PTH
DuBose et al., Artif Organs 1982
(Acid-Base Imbalance...) :
PTH mediates bone buffering capacity by activating intracellular shifts of calcium, phosphorus, and carbonate or by stimulation of bone
carbonic anhydrase
Nascimento et al., J Pharmacol Exp Ther 1977
:
It has been recently demonstrated that
parathyroid hormone (PTH) inhibits renal cortical
carbonic anhydrase ... These data do not support the hypothesis that
PTH inhibits bicarbonate and phosphate reabsorption by
inhibiting carbonic anhydrase
Babich et al., J Cell Biochem 1997
(Osteosarcoma) :
Therefore, the objectives of this study were to determine the effects of PKC modulators and PTH on UMR 106-H5 rat osteoblastic cell morphology, and the relationship between cell shape and
PTH induced
Cai2+ changes